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Mitochondrial Haplogroups and Polymorphisms Reveal No Association with Sporadic Prostate Cancer in a Southern European Population

BACKGROUND: It is known that mitochondria play an important role in certain cancers (prostate, renal, breast, or colorectal) and coronary disease. These organelles play an essential role in apoptosis and the production of reactive oxygen species; in addition, mtDNA also reveals the history of popula...

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Autores principales: Álvarez-Cubero, María Jesús, Saiz Guinaldo, María, Martínez-González, Luís Javier, Álvarez Merino, Juan Carlos, Cózar Olmo, José Manuel, Acosta, José Antonio Lorente
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398884/
https://www.ncbi.nlm.nih.gov/pubmed/22815971
http://dx.doi.org/10.1371/journal.pone.0041201
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author Álvarez-Cubero, María Jesús
Saiz Guinaldo, María
Martínez-González, Luís Javier
Álvarez Merino, Juan Carlos
Cózar Olmo, José Manuel
Acosta, José Antonio Lorente
author_facet Álvarez-Cubero, María Jesús
Saiz Guinaldo, María
Martínez-González, Luís Javier
Álvarez Merino, Juan Carlos
Cózar Olmo, José Manuel
Acosta, José Antonio Lorente
author_sort Álvarez-Cubero, María Jesús
collection PubMed
description BACKGROUND: It is known that mitochondria play an important role in certain cancers (prostate, renal, breast, or colorectal) and coronary disease. These organelles play an essential role in apoptosis and the production of reactive oxygen species; in addition, mtDNA also reveals the history of populations and ancient human migration. All these events and variations in the mitochondrial genome are thought to cause some cancers, including prostate cancer, and also help us to group individuals into common origin groups. The aim of the present study is to analyze the different haplogroups and variations in the sequence in the mitochondrial genome of a southern European population consisting of subjects affected (n = 239) and non-affected (n = 150) by sporadic prostate cancer. METHODOLOGY AND PRINCIPAL FINDINGS: Using primer extension analysis and DNA sequencing, we identified the nine major European haplogroups and CR polymorphisms. The frequencies of the haplogroups did not differ between patients and control cohorts, whereas the CR polymorphism T16356C was significantly higher in patients with PC compared to the controls (p = 0.029). PSA, staging, and Gleason score were associated with none of the nine major European haplogroups. The CR polymorphisms G16129A (p = 0.007) and T16224C (p = 0.022) were significantly associated with Gleason score, whereas T16311C (p = 0.046) was linked with T-stage. CONCLUSIONS AND SIGNIFICANCE: Our results do not suggest that mtDNA haplogroups could be involved in sporadic prostate cancer etiology and pathogenesis as previous studies performed in middle Europe population. Although some significant associations have been obtained in studying CR polymorphisms, further studies should be performed to validate these results.
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spelling pubmed-33988842012-07-19 Mitochondrial Haplogroups and Polymorphisms Reveal No Association with Sporadic Prostate Cancer in a Southern European Population Álvarez-Cubero, María Jesús Saiz Guinaldo, María Martínez-González, Luís Javier Álvarez Merino, Juan Carlos Cózar Olmo, José Manuel Acosta, José Antonio Lorente PLoS One Research Article BACKGROUND: It is known that mitochondria play an important role in certain cancers (prostate, renal, breast, or colorectal) and coronary disease. These organelles play an essential role in apoptosis and the production of reactive oxygen species; in addition, mtDNA also reveals the history of populations and ancient human migration. All these events and variations in the mitochondrial genome are thought to cause some cancers, including prostate cancer, and also help us to group individuals into common origin groups. The aim of the present study is to analyze the different haplogroups and variations in the sequence in the mitochondrial genome of a southern European population consisting of subjects affected (n = 239) and non-affected (n = 150) by sporadic prostate cancer. METHODOLOGY AND PRINCIPAL FINDINGS: Using primer extension analysis and DNA sequencing, we identified the nine major European haplogroups and CR polymorphisms. The frequencies of the haplogroups did not differ between patients and control cohorts, whereas the CR polymorphism T16356C was significantly higher in patients with PC compared to the controls (p = 0.029). PSA, staging, and Gleason score were associated with none of the nine major European haplogroups. The CR polymorphisms G16129A (p = 0.007) and T16224C (p = 0.022) were significantly associated with Gleason score, whereas T16311C (p = 0.046) was linked with T-stage. CONCLUSIONS AND SIGNIFICANCE: Our results do not suggest that mtDNA haplogroups could be involved in sporadic prostate cancer etiology and pathogenesis as previous studies performed in middle Europe population. Although some significant associations have been obtained in studying CR polymorphisms, further studies should be performed to validate these results. Public Library of Science 2012-07-17 /pmc/articles/PMC3398884/ /pubmed/22815971 http://dx.doi.org/10.1371/journal.pone.0041201 Text en Álvarez-Cubero et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Álvarez-Cubero, María Jesús
Saiz Guinaldo, María
Martínez-González, Luís Javier
Álvarez Merino, Juan Carlos
Cózar Olmo, José Manuel
Acosta, José Antonio Lorente
Mitochondrial Haplogroups and Polymorphisms Reveal No Association with Sporadic Prostate Cancer in a Southern European Population
title Mitochondrial Haplogroups and Polymorphisms Reveal No Association with Sporadic Prostate Cancer in a Southern European Population
title_full Mitochondrial Haplogroups and Polymorphisms Reveal No Association with Sporadic Prostate Cancer in a Southern European Population
title_fullStr Mitochondrial Haplogroups and Polymorphisms Reveal No Association with Sporadic Prostate Cancer in a Southern European Population
title_full_unstemmed Mitochondrial Haplogroups and Polymorphisms Reveal No Association with Sporadic Prostate Cancer in a Southern European Population
title_short Mitochondrial Haplogroups and Polymorphisms Reveal No Association with Sporadic Prostate Cancer in a Southern European Population
title_sort mitochondrial haplogroups and polymorphisms reveal no association with sporadic prostate cancer in a southern european population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398884/
https://www.ncbi.nlm.nih.gov/pubmed/22815971
http://dx.doi.org/10.1371/journal.pone.0041201
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