The Aryl Hydrocarbon Receptor Mediates Leflunomide-Induced Growth Inhibition of Melanoma Cells

A novel role of the dihydroorotatedehydrogenase (DHODH) inhibitor leflunomide as a potential anti-melanoma therapy was recently reported (Nature 471∶518-22, 2011). We previously reported that leflunomide strongly activates the transcriptional activity of the Aryl Hydrocarbon Receptor (AhR). We there...

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Detalles Bibliográficos
Autores principales: O’Donnell, Edmond F., Kopparapu, Prasad Rao, Koch, Daniel C., Jang, Hyo Sang, Phillips, Jessica Lynne, Tanguay, Robert L., Kerkvliet, Nancy I., Kolluri, Siva Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398955/
https://www.ncbi.nlm.nih.gov/pubmed/22815870
http://dx.doi.org/10.1371/journal.pone.0040926

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3398955/
https://www.ncbi.nlm.nih.gov/pubmed/22815870
http://dx.doi.org/10.1371/journal.pone.0040926

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