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The Daily Practice of Pancreatic Enzyme Replacement Therapy After Pancreatic Surgery: a Northern European Survey: Enzyme Replacement After Surgery
INTRODUCTION: After pancreatic surgery, up to 80 % of patients will develop exocrine insufficiency. For enzyme supplementation to be effective, prescribing an adequate dose of pancreatic enzymes is mandatory but challenging because the required dose varies. Data on the practice of enzyme replacement...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399077/ https://www.ncbi.nlm.nih.gov/pubmed/22711213 http://dx.doi.org/10.1007/s11605-012-1927-1 |
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author | Sikkens, Edmée C. M. Cahen, Djuna L. van Eijck, Casper Kuipers, Ernst J. Bruno, Marco J. |
author_facet | Sikkens, Edmée C. M. Cahen, Djuna L. van Eijck, Casper Kuipers, Ernst J. Bruno, Marco J. |
author_sort | Sikkens, Edmée C. M. |
collection | PubMed |
description | INTRODUCTION: After pancreatic surgery, up to 80 % of patients will develop exocrine insufficiency. For enzyme supplementation to be effective, prescribing an adequate dose of pancreatic enzymes is mandatory but challenging because the required dose varies. Data on the practice of enzyme replacement therapy after surgery are lacking, and therefore, we conducted this analysis. METHODS: An anonymous survey was distributed to members of the Dutch and German patient associations for pancreatic disorders. The target population consisted of patients with chronic pancreatitis or pancreatic cancer who had undergone pancreatic surgery and were using enzymes to treat exocrine insufficiency. Results were compared to a similar group of non-operated patients. RESULTS: Ninety-one cases were analyzed (84 % underwent a resection procedure). The median daily enzyme dose was 6, and 25 % took three or less capsules. Despite treatment, 68 % of patients reported steatorrhea-related symptoms, 48 % adhered to a non-indicated dietary fat restriction, and only 33 % had visited a dietician. The outcome was equally poor for the 91 non-operated patients. CONCLUSION: Most patients suffering from exocrine insufficiency after pancreatic surgery are undertreated. To improve efficacy, physicians should be more focused on treating exocrine insufficiency and educate patients to adjust the dose according to symptoms and their diet. |
format | Online Article Text |
id | pubmed-3399077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-33990772012-07-25 The Daily Practice of Pancreatic Enzyme Replacement Therapy After Pancreatic Surgery: a Northern European Survey: Enzyme Replacement After Surgery Sikkens, Edmée C. M. Cahen, Djuna L. van Eijck, Casper Kuipers, Ernst J. Bruno, Marco J. J Gastrointest Surg Original Article INTRODUCTION: After pancreatic surgery, up to 80 % of patients will develop exocrine insufficiency. For enzyme supplementation to be effective, prescribing an adequate dose of pancreatic enzymes is mandatory but challenging because the required dose varies. Data on the practice of enzyme replacement therapy after surgery are lacking, and therefore, we conducted this analysis. METHODS: An anonymous survey was distributed to members of the Dutch and German patient associations for pancreatic disorders. The target population consisted of patients with chronic pancreatitis or pancreatic cancer who had undergone pancreatic surgery and were using enzymes to treat exocrine insufficiency. Results were compared to a similar group of non-operated patients. RESULTS: Ninety-one cases were analyzed (84 % underwent a resection procedure). The median daily enzyme dose was 6, and 25 % took three or less capsules. Despite treatment, 68 % of patients reported steatorrhea-related symptoms, 48 % adhered to a non-indicated dietary fat restriction, and only 33 % had visited a dietician. The outcome was equally poor for the 91 non-operated patients. CONCLUSION: Most patients suffering from exocrine insufficiency after pancreatic surgery are undertreated. To improve efficacy, physicians should be more focused on treating exocrine insufficiency and educate patients to adjust the dose according to symptoms and their diet. Springer-Verlag 2012-06-19 2012 /pmc/articles/PMC3399077/ /pubmed/22711213 http://dx.doi.org/10.1007/s11605-012-1927-1 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Article Sikkens, Edmée C. M. Cahen, Djuna L. van Eijck, Casper Kuipers, Ernst J. Bruno, Marco J. The Daily Practice of Pancreatic Enzyme Replacement Therapy After Pancreatic Surgery: a Northern European Survey: Enzyme Replacement After Surgery |
title | The Daily Practice of Pancreatic Enzyme Replacement Therapy After Pancreatic Surgery: a Northern European Survey: Enzyme Replacement After Surgery |
title_full | The Daily Practice of Pancreatic Enzyme Replacement Therapy After Pancreatic Surgery: a Northern European Survey: Enzyme Replacement After Surgery |
title_fullStr | The Daily Practice of Pancreatic Enzyme Replacement Therapy After Pancreatic Surgery: a Northern European Survey: Enzyme Replacement After Surgery |
title_full_unstemmed | The Daily Practice of Pancreatic Enzyme Replacement Therapy After Pancreatic Surgery: a Northern European Survey: Enzyme Replacement After Surgery |
title_short | The Daily Practice of Pancreatic Enzyme Replacement Therapy After Pancreatic Surgery: a Northern European Survey: Enzyme Replacement After Surgery |
title_sort | daily practice of pancreatic enzyme replacement therapy after pancreatic surgery: a northern european survey: enzyme replacement after surgery |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399077/ https://www.ncbi.nlm.nih.gov/pubmed/22711213 http://dx.doi.org/10.1007/s11605-012-1927-1 |
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