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Chemical Modifications in Aggregates of Recombinant Human Insulin Induced by Metal-Catalyzed Oxidation: Covalent Cross-Linking via Michael Addition to Tyrosine Oxidation Products

PURPOSE: To elucidate the chemical modifications in covalent aggregates of recombinant human insulin induced by metal catalyzed oxidation (MCO). METHODS: Insulin was exposed for 3 h at room temperature to the oxidative system copper(II)/ascorbate. Chemical derivatization with 4-(aminomethyl) benzene...

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Detalles Bibliográficos
Autores principales:	Torosantucci, Riccardo, Mozziconacci, Olivier, Sharov, Victor, Schöneich, Christian, Jiskoot, Wim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2012
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399080/ https://www.ncbi.nlm.nih.gov/pubmed/22572797 http://dx.doi.org/10.1007/s11095-012-0755-z

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