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Inflammatory Marker sTREM-1 Reflects the Clinical Stage and Respiratory Tract Obstruction in Allergic Asthma Bronchiale Patients and Correlates with Number of Neutrophils

The knowledge that asthma is an inflammatory disorder has prompted us to investigate the plasma levels of a new inflammatory marker sTREM-1 that is released from the surfaces of activated neutrophils and monocytes. The plasma levels of sTREM-1 were analysed by a sandwich ELISA test in the cohort of...

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Autores principales: Bucova, Maria, Suchankova, Magda, Dzurilla, Martin, Vrlik, Mojmir, Novosadova, Helena, Tedlova, Eva, Urban, Stefan, Hornakova, Edita, Seligova, Marianna, Durmanova, Vladimira, Penz, Peter, Javor, Juraj, Paulovicova, Ema
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399449/
https://www.ncbi.nlm.nih.gov/pubmed/22829716
http://dx.doi.org/10.1155/2012/628754
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author Bucova, Maria
Suchankova, Magda
Dzurilla, Martin
Vrlik, Mojmir
Novosadova, Helena
Tedlova, Eva
Urban, Stefan
Hornakova, Edita
Seligova, Marianna
Durmanova, Vladimira
Penz, Peter
Javor, Juraj
Paulovicova, Ema
author_facet Bucova, Maria
Suchankova, Magda
Dzurilla, Martin
Vrlik, Mojmir
Novosadova, Helena
Tedlova, Eva
Urban, Stefan
Hornakova, Edita
Seligova, Marianna
Durmanova, Vladimira
Penz, Peter
Javor, Juraj
Paulovicova, Ema
author_sort Bucova, Maria
collection PubMed
description The knowledge that asthma is an inflammatory disorder has prompted us to investigate the plasma levels of a new inflammatory marker sTREM-1 that is released from the surfaces of activated neutrophils and monocytes. The plasma levels of sTREM-1 were analysed by a sandwich ELISA test in the cohort of 76 patients with allergic asthma bronchiale and 39 healthy controls. Our results revealed more than 3.5 times higher levels of sTREM-1 in AB patients (92.3 pg/mL ± 125.6) compared with healthy subjects (25.7 pg/mL ± 9.2; P = 0.0001). Higher levels of sTREM-1 were found also in patients with exacerbated AB (170.5 pg/mL ± 78.2) compared with nonexacerbated AB patients (59.1 ± 78.2; P < 0.0001), patients with respiratory tract obstruction (176.4 pg/mL ± 177.8), than those without obstruction (51.99 pg/mL ± 64.0; P < 0.0001) and patients with anti-IgE therapy (P < 0.0001). Levels of sTREM-1 correlated with number of leucocytes (P = 0.002), and absolute number of neutrophils (P = 0.001). Elevated plasma levels of sTREM-1 reflect the severity, state of exacerbation, presence of respiratory tract obstruction in AB patients and together with increased number of neutrophils point to the role of neutrophils in inflammation accompanying AB.
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spelling pubmed-33994492012-07-24 Inflammatory Marker sTREM-1 Reflects the Clinical Stage and Respiratory Tract Obstruction in Allergic Asthma Bronchiale Patients and Correlates with Number of Neutrophils Bucova, Maria Suchankova, Magda Dzurilla, Martin Vrlik, Mojmir Novosadova, Helena Tedlova, Eva Urban, Stefan Hornakova, Edita Seligova, Marianna Durmanova, Vladimira Penz, Peter Javor, Juraj Paulovicova, Ema Mediators Inflamm Research Article The knowledge that asthma is an inflammatory disorder has prompted us to investigate the plasma levels of a new inflammatory marker sTREM-1 that is released from the surfaces of activated neutrophils and monocytes. The plasma levels of sTREM-1 were analysed by a sandwich ELISA test in the cohort of 76 patients with allergic asthma bronchiale and 39 healthy controls. Our results revealed more than 3.5 times higher levels of sTREM-1 in AB patients (92.3 pg/mL ± 125.6) compared with healthy subjects (25.7 pg/mL ± 9.2; P = 0.0001). Higher levels of sTREM-1 were found also in patients with exacerbated AB (170.5 pg/mL ± 78.2) compared with nonexacerbated AB patients (59.1 ± 78.2; P < 0.0001), patients with respiratory tract obstruction (176.4 pg/mL ± 177.8), than those without obstruction (51.99 pg/mL ± 64.0; P < 0.0001) and patients with anti-IgE therapy (P < 0.0001). Levels of sTREM-1 correlated with number of leucocytes (P = 0.002), and absolute number of neutrophils (P = 0.001). Elevated plasma levels of sTREM-1 reflect the severity, state of exacerbation, presence of respiratory tract obstruction in AB patients and together with increased number of neutrophils point to the role of neutrophils in inflammation accompanying AB. Hindawi Publishing Corporation 2012 2012-07-05 /pmc/articles/PMC3399449/ /pubmed/22829716 http://dx.doi.org/10.1155/2012/628754 Text en Copyright © 2012 Maria Bucova et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bucova, Maria
Suchankova, Magda
Dzurilla, Martin
Vrlik, Mojmir
Novosadova, Helena
Tedlova, Eva
Urban, Stefan
Hornakova, Edita
Seligova, Marianna
Durmanova, Vladimira
Penz, Peter
Javor, Juraj
Paulovicova, Ema
Inflammatory Marker sTREM-1 Reflects the Clinical Stage and Respiratory Tract Obstruction in Allergic Asthma Bronchiale Patients and Correlates with Number of Neutrophils
title Inflammatory Marker sTREM-1 Reflects the Clinical Stage and Respiratory Tract Obstruction in Allergic Asthma Bronchiale Patients and Correlates with Number of Neutrophils
title_full Inflammatory Marker sTREM-1 Reflects the Clinical Stage and Respiratory Tract Obstruction in Allergic Asthma Bronchiale Patients and Correlates with Number of Neutrophils
title_fullStr Inflammatory Marker sTREM-1 Reflects the Clinical Stage and Respiratory Tract Obstruction in Allergic Asthma Bronchiale Patients and Correlates with Number of Neutrophils
title_full_unstemmed Inflammatory Marker sTREM-1 Reflects the Clinical Stage and Respiratory Tract Obstruction in Allergic Asthma Bronchiale Patients and Correlates with Number of Neutrophils
title_short Inflammatory Marker sTREM-1 Reflects the Clinical Stage and Respiratory Tract Obstruction in Allergic Asthma Bronchiale Patients and Correlates with Number of Neutrophils
title_sort inflammatory marker strem-1 reflects the clinical stage and respiratory tract obstruction in allergic asthma bronchiale patients and correlates with number of neutrophils
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399449/
https://www.ncbi.nlm.nih.gov/pubmed/22829716
http://dx.doi.org/10.1155/2012/628754
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