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Acute and Chronic Administrations of Rheum palmatum Reduced the Bioavailability of Phenytoin in Rats: A New Herb-Drug Interaction

The rhizome of Rheum palmatum (RP) is a commonly used herb in clinical Chinese medicine. Phenytoin (PHT) is an antiepileptic with narrow therapeutic window. This study investigated the acute and chronic effects of RP on the pharmacokinetics of PHT in rat. Rats were orally administered with PHT (200 ...

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Detalles Bibliográficos
Autores principales:	Chi, Ying-Chang, Juang, Shin-Hun, Chui, Wai Keung, Hou, Yu-Chi, Chao, Pei-Dawn Lee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399570/ https://www.ncbi.nlm.nih.gov/pubmed/22829856 http://dx.doi.org/10.1155/2012/701205

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