The LKB1 Tumor Suppressor Controls Spindle Orientation and Localization of Activated AMPK in Mitotic Epithelial Cells

Orientation of mitotic spindles plays an integral role in determining the relative positions of daughter cells in a tissue. LKB1 is a tumor suppressor that controls cell polarity, metabolism, and microtubule stability. Here, we show that germline LKB1 mutation in mice impairs spindle orientation in...

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Detalles Bibliográficos
Autores principales: Wei, Chongjuan, Bhattaram, Varun Kumar, Igwe, John C., Fleming, Elizabeth, Tirnauer, Jennifer S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399794/
https://www.ncbi.nlm.nih.gov/pubmed/22815934
http://dx.doi.org/10.1371/journal.pone.0041118

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