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Analysing the Role of UVB-Induced Translational Inhibition and PP2Ac Deactivation in NF-κB Signalling Using a Minimal Mathematical Model

Activation of nuclear factor κB (NF-κB) by interleukin-1β (IL-1) usually results in an anti-apoptotic activity that is rapidly terminated by a negative feedback loop involving NF-κB dependent resynthesis of its own inhibitor IκBα. However, apoptosis induced by ultraviolet B radiation (UVB) is not at...

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Detalles Bibliográficos
Autores principales: Witt, Johannes, Konrath, Fabian, Sawodny, Oliver, Ederer, Michael, Kulms, Dagmar, Sauter, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399864/
https://www.ncbi.nlm.nih.gov/pubmed/22815735
http://dx.doi.org/10.1371/journal.pone.0040274

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