Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building

A limitation in traditional stepwise population pharmacokinetic model building is the difficulty in handling interactions between model components. To address this issue, a method was previously introduced which couples NONMEM parameter estimation and model fitness evaluation to a single-objective,...

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Detalles Bibliográficos
Autores principales: Sherer, Eric A., Sale, Mark E., Pollock, Bruce G., Belani, Chandra P., Egorin, Merrill J., Ivy, Percy S., Lieberman, Jeffrey A., Manuck, Stephen B., Marder, Stephen R., Muldoon, Matthew F., Scher, Howard I., Solit, David B., Bies, Robert R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400037/
https://www.ncbi.nlm.nih.gov/pubmed/22767341
http://dx.doi.org/10.1007/s10928-012-9258-0

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