A genome-wide association study identifies susceptibility loci for Wilms tumor

Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor we conducted a genome-wide association study in 757 cases and 1,879 controls. We evaluated ten SNPs in regions significant at P<5×10(−5) in two independent replicati...

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Detalles Bibliográficos
Autores principales: Turnbull, Clare, Perdeaux, Elizabeth, Pernet, David, Naranjo, Arlene, Renwick, Anthony, Seal, Sheila, Xicola, Rosa Maria Munoz, Hanks, Sandra, Slade, Ingrid, Zachariou, Anna, Warren-Perry, Margaret, Ruark, Elise, Gerrard, Mary, Hale, Juliet, Hewitt, Martin, Kohler, Janice, Lane, Sheila, Levitt, Gill, Madi, Mabrook, Morland, Bruce, Neefjes, Veronica, Nicholdson, James, Picton, Susan, Pizer, Barry, Ronghe, Milind, Stevens, Michael, Traunecker, Heidi, Stiller, Charles A, Pritchard-Jones, Kathy, Dome, Jeffrey, Grundy, Paul, Rahman, Nazneen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400150/
https://www.ncbi.nlm.nih.gov/pubmed/22544364
http://dx.doi.org/10.1038/ng.2251
Descripción
Sumario:Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor we conducted a genome-wide association study in 757 cases and 1,879 controls. We evaluated ten SNPs in regions significant at P<5×10(−5) in two independent replication series from the UK (769 cases and 2,814 controls) and the US (719 cases and 1,037 controls). We identified clear significant associations at two loci, 2p24 (rs3755132, P=1.03×10(−14) and rs807624, P=1.32×10(−14)) and 11q14 (rs790356, P=4.25 ×10(−15)). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate signals at 5q14, 22q12 and Xp22.

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