A genome-wide association study identifies susceptibility loci for Wilms tumor

Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor we conducted a genome-wide association study in 757 cases and 1,879 controls. We evaluated ten SNPs in regions significant at P<5×10(−5) in two independent replicati...

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Autores principales: Turnbull, Clare, Perdeaux, Elizabeth, Pernet, David, Naranjo, Arlene, Renwick, Anthony, Seal, Sheila, Xicola, Rosa Maria Munoz, Hanks, Sandra, Slade, Ingrid, Zachariou, Anna, Warren-Perry, Margaret, Ruark, Elise, Gerrard, Mary, Hale, Juliet, Hewitt, Martin, Kohler, Janice, Lane, Sheila, Levitt, Gill, Madi, Mabrook, Morland, Bruce, Neefjes, Veronica, Nicholdson, James, Picton, Susan, Pizer, Barry, Ronghe, Milind, Stevens, Michael, Traunecker, Heidi, Stiller, Charles A, Pritchard-Jones, Kathy, Dome, Jeffrey, Grundy, Paul, Rahman, Nazneen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400150/
https://www.ncbi.nlm.nih.gov/pubmed/22544364
http://dx.doi.org/10.1038/ng.2251
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author Turnbull, Clare
Perdeaux, Elizabeth
Pernet, David
Naranjo, Arlene
Renwick, Anthony
Seal, Sheila
Xicola, Rosa Maria Munoz
Hanks, Sandra
Slade, Ingrid
Zachariou, Anna
Warren-Perry, Margaret
Ruark, Elise
Gerrard, Mary
Hale, Juliet
Hewitt, Martin
Kohler, Janice
Lane, Sheila
Levitt, Gill
Madi, Mabrook
Morland, Bruce
Neefjes, Veronica
Nicholdson, James
Picton, Susan
Pizer, Barry
Ronghe, Milind
Stevens, Michael
Traunecker, Heidi
Stiller, Charles A
Pritchard-Jones, Kathy
Dome, Jeffrey
Grundy, Paul
Rahman, Nazneen
author_facet Turnbull, Clare
Perdeaux, Elizabeth
Pernet, David
Naranjo, Arlene
Renwick, Anthony
Seal, Sheila
Xicola, Rosa Maria Munoz
Hanks, Sandra
Slade, Ingrid
Zachariou, Anna
Warren-Perry, Margaret
Ruark, Elise
Gerrard, Mary
Hale, Juliet
Hewitt, Martin
Kohler, Janice
Lane, Sheila
Levitt, Gill
Madi, Mabrook
Morland, Bruce
Neefjes, Veronica
Nicholdson, James
Picton, Susan
Pizer, Barry
Ronghe, Milind
Stevens, Michael
Traunecker, Heidi
Stiller, Charles A
Pritchard-Jones, Kathy
Dome, Jeffrey
Grundy, Paul
Rahman, Nazneen
author_sort Turnbull, Clare
collection PubMed
description Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor we conducted a genome-wide association study in 757 cases and 1,879 controls. We evaluated ten SNPs in regions significant at P<5×10(−5) in two independent replication series from the UK (769 cases and 2,814 controls) and the US (719 cases and 1,037 controls). We identified clear significant associations at two loci, 2p24 (rs3755132, P=1.03×10(−14) and rs807624, P=1.32×10(−14)) and 11q14 (rs790356, P=4.25 ×10(−15)). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate signals at 5q14, 22q12 and Xp22.
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spelling pubmed-34001502012-12-01 A genome-wide association study identifies susceptibility loci for Wilms tumor Turnbull, Clare Perdeaux, Elizabeth Pernet, David Naranjo, Arlene Renwick, Anthony Seal, Sheila Xicola, Rosa Maria Munoz Hanks, Sandra Slade, Ingrid Zachariou, Anna Warren-Perry, Margaret Ruark, Elise Gerrard, Mary Hale, Juliet Hewitt, Martin Kohler, Janice Lane, Sheila Levitt, Gill Madi, Mabrook Morland, Bruce Neefjes, Veronica Nicholdson, James Picton, Susan Pizer, Barry Ronghe, Milind Stevens, Michael Traunecker, Heidi Stiller, Charles A Pritchard-Jones, Kathy Dome, Jeffrey Grundy, Paul Rahman, Nazneen Nat Genet Article Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor we conducted a genome-wide association study in 757 cases and 1,879 controls. We evaluated ten SNPs in regions significant at P<5×10(−5) in two independent replication series from the UK (769 cases and 2,814 controls) and the US (719 cases and 1,037 controls). We identified clear significant associations at two loci, 2p24 (rs3755132, P=1.03×10(−14) and rs807624, P=1.32×10(−14)) and 11q14 (rs790356, P=4.25 ×10(−15)). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate signals at 5q14, 22q12 and Xp22. 2012-04-29 /pmc/articles/PMC3400150/ /pubmed/22544364 http://dx.doi.org/10.1038/ng.2251 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Turnbull, Clare
Perdeaux, Elizabeth
Pernet, David
Naranjo, Arlene
Renwick, Anthony
Seal, Sheila
Xicola, Rosa Maria Munoz
Hanks, Sandra
Slade, Ingrid
Zachariou, Anna
Warren-Perry, Margaret
Ruark, Elise
Gerrard, Mary
Hale, Juliet
Hewitt, Martin
Kohler, Janice
Lane, Sheila
Levitt, Gill
Madi, Mabrook
Morland, Bruce
Neefjes, Veronica
Nicholdson, James
Picton, Susan
Pizer, Barry
Ronghe, Milind
Stevens, Michael
Traunecker, Heidi
Stiller, Charles A
Pritchard-Jones, Kathy
Dome, Jeffrey
Grundy, Paul
Rahman, Nazneen
A genome-wide association study identifies susceptibility loci for Wilms tumor
title A genome-wide association study identifies susceptibility loci for Wilms tumor
title_full A genome-wide association study identifies susceptibility loci for Wilms tumor
title_fullStr A genome-wide association study identifies susceptibility loci for Wilms tumor
title_full_unstemmed A genome-wide association study identifies susceptibility loci for Wilms tumor
title_short A genome-wide association study identifies susceptibility loci for Wilms tumor
title_sort genome-wide association study identifies susceptibility loci for wilms tumor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400150/
https://www.ncbi.nlm.nih.gov/pubmed/22544364
http://dx.doi.org/10.1038/ng.2251
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