Convenient and Scalable Synthesis of Fmoc-Protected Peptide Nucleic Acid Backbone

The peptide nucleic acid backbone Fmoc-AEG-OBn has been synthesized via a scalable and cost-effective route. Ethylenediamine is mono-Boc protected, then alkylated with benzyl bromoacetate. The Boc group is removed and replaced with an Fmoc group. The synthesis was performed starting with 50 g of Boc...

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Detalles Bibliográficos
Autores principales: Feagin, Trevor A., Shah, Nirmal I., Heemstra, Jennifer M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400375/
https://www.ncbi.nlm.nih.gov/pubmed/22848796
http://dx.doi.org/10.1155/2012/354549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400375/
https://www.ncbi.nlm.nih.gov/pubmed/22848796
http://dx.doi.org/10.1155/2012/354549

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