Cargando…

Convenient and Scalable Synthesis of Fmoc-Protected Peptide Nucleic Acid Backbone

The peptide nucleic acid backbone Fmoc-AEG-OBn has been synthesized via a scalable and cost-effective route. Ethylenediamine is mono-Boc protected, then alkylated with benzyl bromoacetate. The Boc group is removed and replaced with an Fmoc group. The synthesis was performed starting with 50 g of Boc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feagin, Trevor A., Shah, Nirmal I., Heemstra, Jennifer M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400375/ https://www.ncbi.nlm.nih.gov/pubmed/22848796 http://dx.doi.org/10.1155/2012/354549

Ejemplares similares

Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions
por: Heemstra, Jennifer M., et al.
Publicado: (2009)

Mechanically rigid supramolecular assemblies formed from an Fmoc-guanine conjugated peptide nucleic acid
por: Basavalingappa, Vasantha, et al.
Publicado: (2019)

Advances in Fmoc solid‐phase peptide synthesis
por: Behrendt, Raymond, et al.
Publicado: (2016)

Predicting the Success of Fmoc-Based Peptide Synthesis
por: Gutman, Ilanit, et al.
Publicado: (2022)

Evaluation of acid-labile S-protecting groups to prevent Cys racemization in Fmoc solid-phase peptide synthesis
por: Hibino, Hajime, et al.
Publicado: (2014)

Stimuli-responsive assembly of bilingual peptide nucleic acids
por: Argueta-Gonzalez, Hector S., et al.
Publicado: (2022)

Automated synthesis of backbone protected peptides
por: Abdel-Aal, Abu-Baker M., et al.
Publicado: (2014)

Cysteine Pseudoprolines for Thiol Protection and Peptide Macrocyclization Enhancement in Fmoc-Based Solid-Phase Peptide Synthesis
por: Postma, Tobias M., et al.
Publicado: (2014)

A shelf stable Fmoc hydrazine resin for the synthesis of peptide hydrazides
por: Bird, Michael J., et al.
Publicado: (2022)

Development of Fmoc-Protected Bis-Amino Acids toward Automated Synthesis of Highly Functionalized Spiroligomers
por: Xie, Yihui, et al.
Publicado: (2022)

Tea Bags for Fmoc Solid-Phase Peptide Synthesis: An Example of Circular Economy
por: Guzmán, Fanny, et al.
Publicado: (2021)

Chiral Peptide Nucleic Acids with a Substituent in the N-(2-Aminoethy)glycine Backbone
por: Sugiyama, Toru, et al.
Publicado: (2012)

Correction to “Development of Fmoc-Protected Bis-Amino Acids toward Automated Synthesis of Highly Functionalized Spiroligomers”
por: Xie, Yihui, et al.
Publicado: (2023)

Expanding the Functional Scope of the Fmoc‐Diphenylalanine Hydrogelator by Introducing a Rigidifying and Chemically Active Urea Backbone Modification
por: Basavalingappa, Vasantha, et al.
Publicado: (2019)

Glutathione-Triggered Formation of a Fmoc-Protected Short Peptide-Based Supramolecular Hydrogel
por: Shi, Yang, et al.
Publicado: (2014)

Deprotection Reagents in Fmoc Solid Phase Peptide Synthesis: Moving Away from Piperidine?
por: Luna, Omar F., et al.
Publicado: (2016)

Forced Intercalation Peptide Nucleic Acid Probes for the Detection of an Adenosine-to-Inosine Modification
por: Swenson, Colin S., et al.
Publicado: (2022)

Synthesis of Fmoc-Triazine Amino Acids and Its Application in the Synthesis of Short Antibacterial Peptidomimetics
por: Gunasekaran, Pethaiah, et al.
Publicado: (2020)

One-Step Synthesis of 3-(Fmoc-amino acid)-3,4-diaminobenzoic Acids
por: Chien, Min-Cheng, et al.
Publicado: (2023)

A straightforward method for automated Fmoc-based synthesis of bio-inspired peptide crypto-thioesters
por: Terrier, Victor P., et al.
Publicado: (2016)

Dipropylamine for 9-Fluorenylmethyloxycarbonyl (Fmoc) Deprotection with Reduced Aspartimide Formation in Solid-Phase Peptide Synthesis
por: Personne, Hippolyte, et al.
Publicado: (2023)

Efficient Chemical Protein Synthesis using Fmoc‐Masked N‐Terminal Cysteine in Peptide Thioester Segments
por: Kar, Abhisek, et al.
Publicado: (2020)

Optimized Fmoc-Removal Strategy to Suppress the Traceless and Conventional Diketopiperazine Formation in Solid-Phase Peptide Synthesis
por: Yang, Yi, et al.
Publicado: (2022)

Preparation and Application of an Inexpensive α-Formylglycine Building Block Compatible with Fmoc Solid-Phase Peptide Synthesis
por: Yates, Nicholas D. J., et al.
Publicado: (2023)

Mastering Backbone.js: design and build scalable web applications using Backbone.js
por: Echamea, Abiee
Publicado: (2016)

Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology
por: Epple, Sven, et al.
Publicado: (2021)

Efficient Method for the Concentration Determination of Fmoc Groups Incorporated in the Core-Shell Materials by Fmoc–Glycine
por: Szczepańska, Elżbieta, et al.
Publicado: (2020)

Large‐Scale Asymmetric Synthesis of Fmoc‐(S)‐2‐Amino‐6,6,6‐Trifluorohexanoic Acid
por: Yin, Zizhen, et al.
Publicado: (2019)

Optimized syntheses of Fmoc azido amino acids for the preparation of azidopeptides
por: Pícha, Jan, et al.
Publicado: (2017)

Improving Fmoc Solid Phase Synthesis of Human Beta Defensin 3
por: Walewska, Aleksandra, et al.
Publicado: (2022)

The phosphate clamp: a small and independent motif for nucleic acid backbone recognition
por: Komeda, Seiji, et al.
Publicado: (2011)

Unusual Hydrogen Bonding Patterns and the Role of the Backbone in Nucleic Acid Information Transfer
por: Benner, Steven A.
Publicado: (2016)

A versatile strategy for convenient circular bivalent functional nucleic acids construction
por: Zhang, Xiao-Jing, et al.
Publicado: (2022)

A Doubly Fmoc-Protected Aspartic Acid Self-Assembles into Hydrogels Suitable for Bone Tissue Engineering
por: Petropoulou, Katerina, et al.
Publicado: (2022)

Synthesis of HDAC Substrate Peptidomimetic Inhibitors Using Fmoc Amino Acids Incorporating Zinc-Binding Groups
por: Mahindra, Amit, et al.
Publicado: (2019)

Submonomeric Strategy with Minimal Protection for the Synthesis of C(2)-Modified Peptide Nucleic Acids
por: Volpi, Stefano, et al.
Publicado: (2021)

New Physical Hydrogels Based on Co-Assembling of FMOC–Amino Acids
por: Croitoriu, Alexandra, et al.
Publicado: (2021)

Sequence-selective recognition of double-stranded RNA and enhanced cellular uptake of cationic nucleobase and backbone-modified peptide nucleic acids
por: Hnedzko, Dziyana, et al.
Publicado: (2017)

S-Fluorenylmethyl protection of the cysteine side chain upon N(α)-Fmoc deprotection
por: Wehner, Johannes W, et al.
Publicado: (2012)

Biosynthesis and Characterization of Cross-Linked Fmoc Peptide-Based Hydrogels for Drug Delivery Applications
por: Chronopoulou, Laura, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_vn6lsljal5gdshmon5i4fc8hoe