Bicarbonate Plays a Critical Role in the Generation of Cytotoxicity during SIN-1 Decomposition in Culture Medium

3-Morpholinosydnonimine (SIN-1) is used as a donor of peroxynitrite (ONOO(−)) in various studies. We demonstrated, however, that, the cell-culture medium remains cytotoxic to PC12 cells even after almost complete SIN-1 decomposition, suggesting that reaction product(s) in the medium, rather than ONO...

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Detalles Bibliográficos
Autores principales: Shirai, Kyo, Okada, Tatsumi, Konishi, Kanako, Murata, Hiroshi, Akashi, Soichiro, Sugawara, Fumio, Watanabe, Nobuo, Arai, Takao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400428/
https://www.ncbi.nlm.nih.gov/pubmed/22848780
http://dx.doi.org/10.1155/2012/326731

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