A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Sex hormone-binding globulin (SHBG) is a glycoprotein responsible for the transport and biologic availability of sex steroid hormones, primarily testosterone and estradiol. SHBG has been associated with chronic diseases including type 2 diabetes (T2D) and with hormone-sensitive cancers such as breas...

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Autores principales: Coviello, Andrea D., Haring, Robin, Wellons, Melissa, Vaidya, Dhananjay, Lehtimäki, Terho, Keildson, Sarah, Lunetta, Kathryn L., He, Chunyan, Fornage, Myriam, Lagou, Vasiliki, Mangino, Massimo, Onland-Moret, N. Charlotte, Chen, Brian, Eriksson, Joel, Garcia, Melissa, Liu, Yong Mei, Koster, Annemarie, Lohman, Kurt, Lyytikäinen, Leo-Pekka, Petersen, Ann-Kristin, Prescott, Jennifer, Stolk, Lisette, Vandenput, Liesbeth, Wood, Andrew R., Zhuang, Wei Vivian, Ruokonen, Aimo, Hartikainen, Anna-Liisa, Pouta, Anneli, Bandinelli, Stefania, Biffar, Reiner, Brabant, Georg, Cox, David G., Chen, Yuhui, Cummings, Steven, Ferrucci, Luigi, Gunter, Marc J., Hankinson, Susan E., Martikainen, Hannu, Hofman, Albert, Homuth, Georg, Illig, Thomas, Jansson, John-Olov, Johnson, Andrew D., Karasik, David, Karlsson, Magnus, Kettunen, Johannes, Kiel, Douglas P., Kraft, Peter, Liu, Jingmin, Ljunggren, Östen, Lorentzon, Mattias, Maggio, Marcello, Markus, Marcello R. P., Mellström, Dan, Miljkovic, Iva, Mirel, Daniel, Nelson, Sarah, Morin Papunen, Laure, Peeters, Petra H. M., Prokopenko, Inga, Raffel, Leslie, Reincke, Martin, Reiner, Alex P., Rexrode, Kathryn, Rivadeneira, Fernando, Schwartz, Stephen M., Siscovick, David, Soranzo, Nicole, Stöckl, Doris, Tworoger, Shelley, Uitterlinden, André G., van Gils, Carla H., Vasan, Ramachandran S., Wichmann, H.-Erich, Zhai, Guangju, Bhasin, Shalender, Bidlingmaier, Martin, Chanock, Stephen J., De Vivo, Immaculata, Harris, Tamara B., Hunter, David J., Kähönen, Mika, Liu, Simin, Ouyang, Pamela, Spector, Tim D., van der Schouw, Yvonne T., Viikari, Jorma, Wallaschofski, Henri, McCarthy, Mark I., Frayling, Timothy M., Murray, Anna, Franks, Steve, Järvelin, Marjo-Riitta, de Jong, Frank H., Raitakari, Olli, Teumer, Alexander, Ohlsson, Claes, Murabito, Joanne M., Perry, John R. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400553/
https://www.ncbi.nlm.nih.gov/pubmed/22829776
http://dx.doi.org/10.1371/journal.pgen.1002805

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