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Genomic Data Reveal a Complex Making of Humans

In the last few years, two paradigms underlying human evolution have crumbled. Modern humans have not totally replaced previous hominins without any admixture, and the expected signatures of adaptations to new environments are surprisingly lacking at the genomic level. Here we review current evidenc...

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Detalles Bibliográficos
Autores principales: Alves, Isabel, Šrámková Hanulová, Anna, Foll, Matthieu, Excoffier, Laurent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400556/
https://www.ncbi.nlm.nih.gov/pubmed/22829785
http://dx.doi.org/10.1371/journal.pgen.1002837
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author Alves, Isabel
Šrámková Hanulová, Anna
Foll, Matthieu
Excoffier, Laurent
author_facet Alves, Isabel
Šrámková Hanulová, Anna
Foll, Matthieu
Excoffier, Laurent
author_sort Alves, Isabel
collection PubMed
description In the last few years, two paradigms underlying human evolution have crumbled. Modern humans have not totally replaced previous hominins without any admixture, and the expected signatures of adaptations to new environments are surprisingly lacking at the genomic level. Here we review current evidence about archaic admixture and lack of strong selective sweeps in humans. We underline the need to properly model differential admixture in various populations to correctly reconstruct past demography. We also stress the importance of taking into account the spatial dimension of human evolution, which proceeded by a series of range expansions that could have promoted both the introgression of archaic genes and background selection.
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spelling pubmed-34005562012-07-24 Genomic Data Reveal a Complex Making of Humans Alves, Isabel Šrámková Hanulová, Anna Foll, Matthieu Excoffier, Laurent PLoS Genet Review In the last few years, two paradigms underlying human evolution have crumbled. Modern humans have not totally replaced previous hominins without any admixture, and the expected signatures of adaptations to new environments are surprisingly lacking at the genomic level. Here we review current evidence about archaic admixture and lack of strong selective sweeps in humans. We underline the need to properly model differential admixture in various populations to correctly reconstruct past demography. We also stress the importance of taking into account the spatial dimension of human evolution, which proceeded by a series of range expansions that could have promoted both the introgression of archaic genes and background selection. Public Library of Science 2012-07-19 /pmc/articles/PMC3400556/ /pubmed/22829785 http://dx.doi.org/10.1371/journal.pgen.1002837 Text en Alves et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Review
Alves, Isabel
Šrámková Hanulová, Anna
Foll, Matthieu
Excoffier, Laurent
Genomic Data Reveal a Complex Making of Humans
title Genomic Data Reveal a Complex Making of Humans
title_full Genomic Data Reveal a Complex Making of Humans
title_fullStr Genomic Data Reveal a Complex Making of Humans
title_full_unstemmed Genomic Data Reveal a Complex Making of Humans
title_short Genomic Data Reveal a Complex Making of Humans
title_sort genomic data reveal a complex making of humans
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400556/
https://www.ncbi.nlm.nih.gov/pubmed/22829785
http://dx.doi.org/10.1371/journal.pgen.1002837
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