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Genomic Data Reveal a Complex Making of Humans
In the last few years, two paradigms underlying human evolution have crumbled. Modern humans have not totally replaced previous hominins without any admixture, and the expected signatures of adaptations to new environments are surprisingly lacking at the genomic level. Here we review current evidenc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400556/ https://www.ncbi.nlm.nih.gov/pubmed/22829785 http://dx.doi.org/10.1371/journal.pgen.1002837 |
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author | Alves, Isabel Šrámková Hanulová, Anna Foll, Matthieu Excoffier, Laurent |
author_facet | Alves, Isabel Šrámková Hanulová, Anna Foll, Matthieu Excoffier, Laurent |
author_sort | Alves, Isabel |
collection | PubMed |
description | In the last few years, two paradigms underlying human evolution have crumbled. Modern humans have not totally replaced previous hominins without any admixture, and the expected signatures of adaptations to new environments are surprisingly lacking at the genomic level. Here we review current evidence about archaic admixture and lack of strong selective sweeps in humans. We underline the need to properly model differential admixture in various populations to correctly reconstruct past demography. We also stress the importance of taking into account the spatial dimension of human evolution, which proceeded by a series of range expansions that could have promoted both the introgression of archaic genes and background selection. |
format | Online Article Text |
id | pubmed-3400556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34005562012-07-24 Genomic Data Reveal a Complex Making of Humans Alves, Isabel Šrámková Hanulová, Anna Foll, Matthieu Excoffier, Laurent PLoS Genet Review In the last few years, two paradigms underlying human evolution have crumbled. Modern humans have not totally replaced previous hominins without any admixture, and the expected signatures of adaptations to new environments are surprisingly lacking at the genomic level. Here we review current evidence about archaic admixture and lack of strong selective sweeps in humans. We underline the need to properly model differential admixture in various populations to correctly reconstruct past demography. We also stress the importance of taking into account the spatial dimension of human evolution, which proceeded by a series of range expansions that could have promoted both the introgression of archaic genes and background selection. Public Library of Science 2012-07-19 /pmc/articles/PMC3400556/ /pubmed/22829785 http://dx.doi.org/10.1371/journal.pgen.1002837 Text en Alves et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Review Alves, Isabel Šrámková Hanulová, Anna Foll, Matthieu Excoffier, Laurent Genomic Data Reveal a Complex Making of Humans |
title | Genomic Data Reveal a Complex Making of Humans |
title_full | Genomic Data Reveal a Complex Making of Humans |
title_fullStr | Genomic Data Reveal a Complex Making of Humans |
title_full_unstemmed | Genomic Data Reveal a Complex Making of Humans |
title_short | Genomic Data Reveal a Complex Making of Humans |
title_sort | genomic data reveal a complex making of humans |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400556/ https://www.ncbi.nlm.nih.gov/pubmed/22829785 http://dx.doi.org/10.1371/journal.pgen.1002837 |
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