GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program

The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show...

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Detalles Bibliográficos
Autores principales: Hopkin, Amelia Soto, Gordon, William, Klein, Rachel Herndon, Espitia, Francisco, Daily, Kenneth, Zeller, Michael, Baldi, Pierre, Andersen, Bogi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400561/
https://www.ncbi.nlm.nih.gov/pubmed/22829784
http://dx.doi.org/10.1371/journal.pgen.1002829
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author Hopkin, Amelia Soto
Gordon, William
Klein, Rachel Herndon
Espitia, Francisco
Daily, Kenneth
Zeller, Michael
Baldi, Pierre
Andersen, Bogi
author_facet Hopkin, Amelia Soto
Gordon, William
Klein, Rachel Herndon
Espitia, Francisco
Daily, Kenneth
Zeller, Michael
Baldi, Pierre
Andersen, Bogi
author_sort Hopkin, Amelia Soto
collection PubMed
description The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show that Trithorax is also a key regulator of epidermal differentiation, not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent of regulation by Polycomb. The differentiation associated transcription factor GRHL3/GET1 recruits the ubiquitously expressed Trithorax complex to a subset of differentiation genes.
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spelling pubmed-34005612012-07-24 GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program Hopkin, Amelia Soto Gordon, William Klein, Rachel Herndon Espitia, Francisco Daily, Kenneth Zeller, Michael Baldi, Pierre Andersen, Bogi PLoS Genet Research Article The antagonistic actions of Polycomb and Trithorax are responsible for proper cell fate determination in mammalian tissues. In the epidermis, a self-renewing epithelium, previous work has shown that release from Polycomb repression only partially explains differentiation gene activation. We now show that Trithorax is also a key regulator of epidermal differentiation, not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent of regulation by Polycomb. The differentiation associated transcription factor GRHL3/GET1 recruits the ubiquitously expressed Trithorax complex to a subset of differentiation genes. Public Library of Science 2012-07-19 /pmc/articles/PMC3400561/ /pubmed/22829784 http://dx.doi.org/10.1371/journal.pgen.1002829 Text en Hopkin et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hopkin, Amelia Soto
Gordon, William
Klein, Rachel Herndon
Espitia, Francisco
Daily, Kenneth
Zeller, Michael
Baldi, Pierre
Andersen, Bogi
GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program
title GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program
title_full GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program
title_fullStr GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program
title_full_unstemmed GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program
title_short GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program
title_sort grhl3/get1 and trithorax group members collaborate to activate the epidermal progenitor differentiation program
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400561/
https://www.ncbi.nlm.nih.gov/pubmed/22829784
http://dx.doi.org/10.1371/journal.pgen.1002829
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