GDP Release Preferentially Occurs on the Phosphate Side in Heterotrimeric G-proteins

After extra-cellular stimulation of G-Protein Coupled Receptors (GPCRs), GDP/GTP exchange appears as the key, rate limiting step of the intracellular activation cycle of heterotrimeric G-proteins. Despite the availability of a large number of X-ray structures, the mechanism of GDP release out of het...

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Detalles Bibliográficos
Autores principales: Louet, Maxime, Martinez, Jean, Floquet, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400569/
https://www.ncbi.nlm.nih.gov/pubmed/22829757
http://dx.doi.org/10.1371/journal.pcbi.1002595

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