High Avidity Cytotoxic T Lymphocytes Can Be Selected into the Memory Pool but They Are Exquisitely Sensitive to Functional Impairment

High avidity cytotoxic T lymphocytes (CTL) are important in viral clearance and anti-tumor immunity, however, mechanisms for their optimal generation and maintenance in vivo remain unclear. Immunizing mice with an antibody-DNA vaccine encoding a single CTL epitope, induces a 100 fold higher avidity...

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Detalles Bibliográficos
Autores principales: Brentville, Victoria A., Metheringham, Rachael L., Gunn, Barbara, Durrant, Lindy G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400594/
https://www.ncbi.nlm.nih.gov/pubmed/22829916
http://dx.doi.org/10.1371/journal.pone.0041112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400594/
https://www.ncbi.nlm.nih.gov/pubmed/22829916
http://dx.doi.org/10.1371/journal.pone.0041112

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