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T(H)17, T(H)22 and T(Reg) Cells Are Enriched in the Healthy Human Cecum

There is increasing evidence that dysregulation of CD4(+) T cell populations leads to intestinal inflammation, but the regional distribution of these populations throughout the intestinal tract in healthy individuals remains unclear. Here, we show that T(H)17, T(H)22 and T(Reg) cells are enriched in...

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Autores principales: Wolff, Martin J., Leung, Jacqueline M., Davenport, Michael, Poles, Michael A., Cho, Ilseung, Loke, P'ng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400627/
https://www.ncbi.nlm.nih.gov/pubmed/22829946
http://dx.doi.org/10.1371/journal.pone.0041373
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author Wolff, Martin J.
Leung, Jacqueline M.
Davenport, Michael
Poles, Michael A.
Cho, Ilseung
Loke, P'ng
author_facet Wolff, Martin J.
Leung, Jacqueline M.
Davenport, Michael
Poles, Michael A.
Cho, Ilseung
Loke, P'ng
author_sort Wolff, Martin J.
collection PubMed
description There is increasing evidence that dysregulation of CD4(+) T cell populations leads to intestinal inflammation, but the regional distribution of these populations throughout the intestinal tract in healthy individuals remains unclear. Here, we show that T(H)17, T(H)22 and T(Reg) cells are enriched in the healthy human cecum compared to the terminal ileum and sigmoid colon, whereas T(H)1 and T(H)2 cells do not significantly vary by location. Transcriptional profiling analysis of paired pinch biopsies from different regions of the intestine identified significant differences in the metabolic state of the terminal ileum, cecum, and sigmoid colon. An increased proportion of T(H)17 cells was positively associated with expression of resistin (RETN) and negatively associated with expression of trefoil factor 1 (TFF1). These results suggest that CD4(+) T helper cells that are important in maintaining mucosal barrier function may be enriched in the cecum as a result of metabolic differences of the surrounding microenvironment.
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spelling pubmed-34006272012-07-24 T(H)17, T(H)22 and T(Reg) Cells Are Enriched in the Healthy Human Cecum Wolff, Martin J. Leung, Jacqueline M. Davenport, Michael Poles, Michael A. Cho, Ilseung Loke, P'ng PLoS One Research Article There is increasing evidence that dysregulation of CD4(+) T cell populations leads to intestinal inflammation, but the regional distribution of these populations throughout the intestinal tract in healthy individuals remains unclear. Here, we show that T(H)17, T(H)22 and T(Reg) cells are enriched in the healthy human cecum compared to the terminal ileum and sigmoid colon, whereas T(H)1 and T(H)2 cells do not significantly vary by location. Transcriptional profiling analysis of paired pinch biopsies from different regions of the intestine identified significant differences in the metabolic state of the terminal ileum, cecum, and sigmoid colon. An increased proportion of T(H)17 cells was positively associated with expression of resistin (RETN) and negatively associated with expression of trefoil factor 1 (TFF1). These results suggest that CD4(+) T helper cells that are important in maintaining mucosal barrier function may be enriched in the cecum as a result of metabolic differences of the surrounding microenvironment. Public Library of Science 2012-07-19 /pmc/articles/PMC3400627/ /pubmed/22829946 http://dx.doi.org/10.1371/journal.pone.0041373 Text en Wolff et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wolff, Martin J.
Leung, Jacqueline M.
Davenport, Michael
Poles, Michael A.
Cho, Ilseung
Loke, P'ng
T(H)17, T(H)22 and T(Reg) Cells Are Enriched in the Healthy Human Cecum
title T(H)17, T(H)22 and T(Reg) Cells Are Enriched in the Healthy Human Cecum
title_full T(H)17, T(H)22 and T(Reg) Cells Are Enriched in the Healthy Human Cecum
title_fullStr T(H)17, T(H)22 and T(Reg) Cells Are Enriched in the Healthy Human Cecum
title_full_unstemmed T(H)17, T(H)22 and T(Reg) Cells Are Enriched in the Healthy Human Cecum
title_short T(H)17, T(H)22 and T(Reg) Cells Are Enriched in the Healthy Human Cecum
title_sort t(h)17, t(h)22 and t(reg) cells are enriched in the healthy human cecum
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400627/
https://www.ncbi.nlm.nih.gov/pubmed/22829946
http://dx.doi.org/10.1371/journal.pone.0041373
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