Cargando…

Chronic Kidney Disease-Induced Cardiac Fibrosis Is Ameliorated by Reducing Circulating Levels of a Non-Dialysable Uremic Toxin, Indoxyl Sulfate

Cardiovascular death commonly occurs in patients with chronic kidney disease. Indoxyl sulfate (IS), a uremic toxin, has been demonstrated in vitro as a contributory factor in cardiac fibrosis, a typical pathological finding in uremic cardiomyopathy. This study aimed to determine if cardiac fibrosis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lekawanvijit, Suree, Kompa, Andrew R., Manabe, Minako, Wang, Bing H., Langham, Robyn G., Nishijima, Fuyuhiko, Kelly, Darren J., Krum, Henry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400638/ https://www.ncbi.nlm.nih.gov/pubmed/22829936 http://dx.doi.org/10.1371/journal.pone.0041281

Ejemplares similares

The Uremic Toxin Adsorbent AST-120 Abrogates Cardiorenal Injury Following Myocardial Infarction
por: Lekawanvijit, Suree, et al.
Publicado: (2013)

Contribution of microRNA to pathological fibrosis in cardio-renal syndrome: impact of uremic toxins
por: Rana, Indrajeetsinh, et al.
Publicado: (2015)

Contribution of microRNA to pathological fibrosis in cardio-renal syndrome: impact of uremic toxins
por: Rana, Indrajeetsinh, et al.
Publicado: (2015)

Indoxyl sulfate, a uremic toxin, downregulates renal expression of Nrf2 through activation of NF-κB
por: Bolati, Dilinaer, et al.
Publicado: (2013)

Cardiotoxicity of Uremic Toxins: A Driver of Cardiorenal Syndrome
por: Lekawanvijit, Suree
Publicado: (2018)

Binding Affinity and Capacity for the Uremic Toxin Indoxyl Sulfate
por: Devine, Eric, et al.
Publicado: (2014)

Triggering of suicidal erythrocyte death by uremic toxin indoxyl sulfate
por: Ahmed, Mohamed Siyabeldin E, et al.
Publicado: (2013)

Neurobehavioral effects of uremic toxin–indoxyl sulfate in the rat model
por: Karbowska, Malgorzata, et al.
Publicado: (2020)

Indoxyl Sulfate, a Uremic Endotheliotoxin
por: Lano, Guillaume, et al.
Publicado: (2020)

The Uremic Toxin Indoxyl Sulfate Accelerates Senescence in Kidney Proximal Tubule Cells
por: Yang, Yi, et al.
Publicado: (2023)

Effects of Sevelamer Hydrochloride on Uremic Toxins Serum Indoxyl Sulfate and P-Cresyl Sulfate in Hemodialysis Patients
por: Lin, Cheng-Jui, et al.
Publicado: (2017)

Uremic Toxin Indoxyl Sulfate Impairs Hydrogen Sulfide Formation in Renal Tubular Cells
por: Lu, Chien-Lin, et al.
Publicado: (2022)

Dialysate With High Dissolved Hydrogen Facilitates Dissociation of Indoxyl Sulfate From Albumin
por: Tange, Yoshihiro, et al.
Publicado: (2015)

SLC22A11 Inserts the Uremic Toxins Indoxyl Sulfate and P-Cresol Sulfate into the Plasma Membrane
por: Tust, Maurice, et al.
Publicado: (2023)

Podocyte Injury Caused by Indoxyl Sulfate, a Uremic Toxin and Aryl-Hydrocarbon Receptor Ligand
por: Ichii, Osamu, et al.
Publicado: (2014)

The Uremic Toxin Indoxyl Sulfate Accelerates Thrombotic Response after Vascular Injury in Animal Models
por: Karbowska, Malgorzata, et al.
Publicado: (2017)

TRPV1 Hyperfunction Involved in Uremic Toxin Indoxyl Sulfate-Mediated Renal Tubular Damage
por: Lu, Chien-Lin, et al.
Publicado: (2020)

Uremic toxin indoxyl sulfate promotes proinflammatory macrophage activation by regulation of β-catenin and YAP pathways
por: Li, Ying, et al.
Publicado: (2021)

Gut-Derived Uremic Toxins in CKD: An Improved Approach for the Evaluation of Serum Indoxyl Sulfate in Clinical Practice
por: Caggiano, Gianvito, et al.
Publicado: (2023)

Uremic Toxin Indoxyl Sulfate Promotes Macrophage-Associated Low-Grade Inflammation and Epithelial Cell Senescence
por: Ribeiro, Andrea, et al.
Publicado: (2023)

Adsorption of uremic toxins using biochar for dialysate regeneration
por: Wang, Wei, et al.
Publicado: (2021)

The Uremic Toxin Indoxyl Sulphate Enhances Macrophage Response to LPS
por: Adesso, Simona, et al.
Publicado: (2013)

Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption
por: Watanabe, Kenta, et al.
Publicado: (2017)

Effects of the uremic toxin indoxyl sulphate on human microvascular endothelial cells
por: Colombo, Graziano, et al.
Publicado: (2022)

Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endothelial Dysfunction in Rat Aortic Rings
por: Nguyen, Cindy, et al.
Publicado: (2022)

Treatment with Paracetamol Can Interfere with the Intradialytic Optical Estimation in Spent Dialysate of Uric Acid but Not of Indoxyl Sulfate
por: Adoberg, Annika, et al.
Publicado: (2022)

Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease
por: Kamiński, Tomasz W., et al.
Publicado: (2017)

Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression
por: Takada, T., et al.
Publicado: (2018)

Functional Genomic Analysis Identifies Indoxyl Sulfate as a Major, Poorly Dialyzable Uremic Toxin in End-Stage Renal Disease
por: Jhawar, Sachin, et al.
Publicado: (2015)

Possible Effects of Uremic Toxins p-Cresol, Indoxyl Sulfate, p-Cresyl Sulfate on the Development and Progression of Colon Cancer in Patients with Chronic Renal Failure
por: Di Paola, Rossella, et al.
Publicado: (2023)

Mixed Matrix Membranes Adsorbers (MMMAs) for the Removal of Uremic Toxins from Dialysate
por: De Pascale, Matilde, et al.
Publicado: (2022)

The impact of antihypertensive pharmacotherapy on interplay between protein-bound uremic toxin (indoxyl sulfate) and markers of inflammation in patients with chronic kidney disease
por: Kaminski, Tomasz W., et al.
Publicado: (2019)

Metabolic alterations by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease
por: Sato, Emiko, et al.
Publicado: (2016)

Lactobacillus salivarius BP121 prevents cisplatin-induced acute kidney injury by inhibition of uremic toxins such as indoxyl sulfate and p-cresol sulfate via alleviating dysbiosis
por: Lee, Tae-Hee, et al.
Publicado: (2020)

Indoxyl Sulfate Downregulates Expression of Mas Receptor via OAT3/AhR/Stat3 Pathway in Proximal Tubular Cells
por: Ng, Hwee-Yeong, et al.
Publicado: (2014)

Uremic Retention Solute Indoxyl Sulfate Level Is Associated with Prolonged QTc Interval in Early CKD Patients
por: Tang, Wei-Hua, et al.
Publicado: (2015)

Indoxyl sulfate, a gut microbiome-derived uremic toxin, is associated with psychic anxiety and its functional magnetic resonance imaging-based neurologic signature
por: Brydges, Christopher R., et al.
Publicado: (2021)

Indoxyl Sulfate-Induced Activation of (Pro)renin Receptor Promotes Cell Proliferation and Tissue Factor Expression in Vascular Smooth Muscle Cells
por: Yisireyili, Maimaiti, et al.
Publicado: (2014)

Indoxyl Sulfate, a Tubular Toxin, Contributes to the Development of Chronic Kidney Disease
por: Cheng, Tong-Hong, et al.
Publicado: (2020)

Comment on Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies. Toxins 2016, 8, 358
por: Barreto, Fellype C., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_m73a7dsfr49g5p36o59l9jsf5o