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Generalization of the Dynamic Clamp Concept in Neurophysiology and Behavior

The idea of closed-loop interaction in in vitro and in vivo electrophysiology has been successfully implemented in the dynamic clamp concept strongly impacting the research of membrane and synaptic properties of neurons. In this paper we show that this concept can be easily generalized to build othe...

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Autores principales: Chamorro, Pablo, Muñiz, Carlos, Levi, Rafael, Arroyo, David, Rodríguez, Francisco B., Varona, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400657/
https://www.ncbi.nlm.nih.gov/pubmed/22829895
http://dx.doi.org/10.1371/journal.pone.0040887
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author Chamorro, Pablo
Muñiz, Carlos
Levi, Rafael
Arroyo, David
Rodríguez, Francisco B.
Varona, Pablo
author_facet Chamorro, Pablo
Muñiz, Carlos
Levi, Rafael
Arroyo, David
Rodríguez, Francisco B.
Varona, Pablo
author_sort Chamorro, Pablo
collection PubMed
description The idea of closed-loop interaction in in vitro and in vivo electrophysiology has been successfully implemented in the dynamic clamp concept strongly impacting the research of membrane and synaptic properties of neurons. In this paper we show that this concept can be easily generalized to build other kinds of closed-loop protocols beyond (or in addition to) electrical stimulation and recording in neurophysiology and behavioral studies for neuroethology. In particular, we illustrate three different examples of goal-driven real-time closed-loop interactions with drug microinjectors, mechanical devices and video event driven stimulation. Modern activity-dependent stimulation protocols can be used to reveal dynamics (otherwise hidden under traditional stimulation techniques), achieve control of natural and pathological states, induce learning, bridge between disparate levels of analysis and for a further automation of experiments. We argue that closed-loop interaction calls for novel real time analysis, prediction and control tools and a new perspective for designing stimulus-response experiments, which can have a large impact in neuroscience research.
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spelling pubmed-34006572012-07-24 Generalization of the Dynamic Clamp Concept in Neurophysiology and Behavior Chamorro, Pablo Muñiz, Carlos Levi, Rafael Arroyo, David Rodríguez, Francisco B. Varona, Pablo PLoS One Research Article The idea of closed-loop interaction in in vitro and in vivo electrophysiology has been successfully implemented in the dynamic clamp concept strongly impacting the research of membrane and synaptic properties of neurons. In this paper we show that this concept can be easily generalized to build other kinds of closed-loop protocols beyond (or in addition to) electrical stimulation and recording in neurophysiology and behavioral studies for neuroethology. In particular, we illustrate three different examples of goal-driven real-time closed-loop interactions with drug microinjectors, mechanical devices and video event driven stimulation. Modern activity-dependent stimulation protocols can be used to reveal dynamics (otherwise hidden under traditional stimulation techniques), achieve control of natural and pathological states, induce learning, bridge between disparate levels of analysis and for a further automation of experiments. We argue that closed-loop interaction calls for novel real time analysis, prediction and control tools and a new perspective for designing stimulus-response experiments, which can have a large impact in neuroscience research. Public Library of Science 2012-07-19 /pmc/articles/PMC3400657/ /pubmed/22829895 http://dx.doi.org/10.1371/journal.pone.0040887 Text en Chamorro et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Chamorro, Pablo
Muñiz, Carlos
Levi, Rafael
Arroyo, David
Rodríguez, Francisco B.
Varona, Pablo
Generalization of the Dynamic Clamp Concept in Neurophysiology and Behavior
title Generalization of the Dynamic Clamp Concept in Neurophysiology and Behavior
title_full Generalization of the Dynamic Clamp Concept in Neurophysiology and Behavior
title_fullStr Generalization of the Dynamic Clamp Concept in Neurophysiology and Behavior
title_full_unstemmed Generalization of the Dynamic Clamp Concept in Neurophysiology and Behavior
title_short Generalization of the Dynamic Clamp Concept in Neurophysiology and Behavior
title_sort generalization of the dynamic clamp concept in neurophysiology and behavior
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400657/
https://www.ncbi.nlm.nih.gov/pubmed/22829895
http://dx.doi.org/10.1371/journal.pone.0040887
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