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In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats
The aim of the present study was to evaluate the response of surrounding tissues to newly developed poly(trimethylene carbonate) (PTMC) membranes. Furthermore, the tissue formation beneath and the space maintaining properties of the PTMC membrane were evaluated. Results were compared with a collagen...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400755/ https://www.ncbi.nlm.nih.gov/pubmed/22569734 http://dx.doi.org/10.1007/s10856-012-4663-x |
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author | Van Leeuwen, A. C. Van Kooten, T. G. Grijpma, D. W. Bos, R. R. M. |
author_facet | Van Leeuwen, A. C. Van Kooten, T. G. Grijpma, D. W. Bos, R. R. M. |
author_sort | Van Leeuwen, A. C. |
collection | PubMed |
description | The aim of the present study was to evaluate the response of surrounding tissues to newly developed poly(trimethylene carbonate) (PTMC) membranes. Furthermore, the tissue formation beneath and the space maintaining properties of the PTMC membrane were evaluated. Results were compared with a collagen membrane (Geistlich BioGide), which served as control. Single-sided standardized 5.0 mm circular bicortical defects were created in the mandibular angle of rats. Defects were covered with either the PTMC membrane or a collagen membrane. After 2, 4 and 12 weeks rats were sacrificed and histology was performed. The PTMC membranes induced a mild tissue reaction corresponding to a normal foreign body reaction. The PTMC membranes showed minimal cellular capsule formation and showed signs of a surface erosion process. Bone tissue formed beneath the PTMC membranes comparable to that beneath the collagen membranes. The space maintaining properties of the PTMC membranes were superior to those of the collagen membrane. Newly developed PTMC membranes can be used with success as barrier membranes in critical size rat mandibular defects. |
format | Online Article Text |
id | pubmed-3400755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-34007552012-08-06 In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats Van Leeuwen, A. C. Van Kooten, T. G. Grijpma, D. W. Bos, R. R. M. J Mater Sci Mater Med Article The aim of the present study was to evaluate the response of surrounding tissues to newly developed poly(trimethylene carbonate) (PTMC) membranes. Furthermore, the tissue formation beneath and the space maintaining properties of the PTMC membrane were evaluated. Results were compared with a collagen membrane (Geistlich BioGide), which served as control. Single-sided standardized 5.0 mm circular bicortical defects were created in the mandibular angle of rats. Defects were covered with either the PTMC membrane or a collagen membrane. After 2, 4 and 12 weeks rats were sacrificed and histology was performed. The PTMC membranes induced a mild tissue reaction corresponding to a normal foreign body reaction. The PTMC membranes showed minimal cellular capsule formation and showed signs of a surface erosion process. Bone tissue formed beneath the PTMC membranes comparable to that beneath the collagen membranes. The space maintaining properties of the PTMC membranes were superior to those of the collagen membrane. Newly developed PTMC membranes can be used with success as barrier membranes in critical size rat mandibular defects. Springer US 2012-05-09 2012 /pmc/articles/PMC3400755/ /pubmed/22569734 http://dx.doi.org/10.1007/s10856-012-4663-x Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Article Van Leeuwen, A. C. Van Kooten, T. G. Grijpma, D. W. Bos, R. R. M. In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats |
title | In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats |
title_full | In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats |
title_fullStr | In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats |
title_full_unstemmed | In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats |
title_short | In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats |
title_sort | in vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400755/ https://www.ncbi.nlm.nih.gov/pubmed/22569734 http://dx.doi.org/10.1007/s10856-012-4663-x |
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