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In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats

The aim of the present study was to evaluate the response of surrounding tissues to newly developed poly(trimethylene carbonate) (PTMC) membranes. Furthermore, the tissue formation beneath and the space maintaining properties of the PTMC membrane were evaluated. Results were compared with a collagen...

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Autores principales: Van Leeuwen, A. C., Van Kooten, T. G., Grijpma, D. W., Bos, R. R. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400755/
https://www.ncbi.nlm.nih.gov/pubmed/22569734
http://dx.doi.org/10.1007/s10856-012-4663-x
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author Van Leeuwen, A. C.
Van Kooten, T. G.
Grijpma, D. W.
Bos, R. R. M.
author_facet Van Leeuwen, A. C.
Van Kooten, T. G.
Grijpma, D. W.
Bos, R. R. M.
author_sort Van Leeuwen, A. C.
collection PubMed
description The aim of the present study was to evaluate the response of surrounding tissues to newly developed poly(trimethylene carbonate) (PTMC) membranes. Furthermore, the tissue formation beneath and the space maintaining properties of the PTMC membrane were evaluated. Results were compared with a collagen membrane (Geistlich BioGide), which served as control. Single-sided standardized 5.0 mm circular bicortical defects were created in the mandibular angle of rats. Defects were covered with either the PTMC membrane or a collagen membrane. After 2, 4 and 12 weeks rats were sacrificed and histology was performed. The PTMC membranes induced a mild tissue reaction corresponding to a normal foreign body reaction. The PTMC membranes showed minimal cellular capsule formation and showed signs of a surface erosion process. Bone tissue formed beneath the PTMC membranes comparable to that beneath the collagen membranes. The space maintaining properties of the PTMC membranes were superior to those of the collagen membrane. Newly developed PTMC membranes can be used with success as barrier membranes in critical size rat mandibular defects.
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spelling pubmed-34007552012-08-06 In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats Van Leeuwen, A. C. Van Kooten, T. G. Grijpma, D. W. Bos, R. R. M. J Mater Sci Mater Med Article The aim of the present study was to evaluate the response of surrounding tissues to newly developed poly(trimethylene carbonate) (PTMC) membranes. Furthermore, the tissue formation beneath and the space maintaining properties of the PTMC membrane were evaluated. Results were compared with a collagen membrane (Geistlich BioGide), which served as control. Single-sided standardized 5.0 mm circular bicortical defects were created in the mandibular angle of rats. Defects were covered with either the PTMC membrane or a collagen membrane. After 2, 4 and 12 weeks rats were sacrificed and histology was performed. The PTMC membranes induced a mild tissue reaction corresponding to a normal foreign body reaction. The PTMC membranes showed minimal cellular capsule formation and showed signs of a surface erosion process. Bone tissue formed beneath the PTMC membranes comparable to that beneath the collagen membranes. The space maintaining properties of the PTMC membranes were superior to those of the collagen membrane. Newly developed PTMC membranes can be used with success as barrier membranes in critical size rat mandibular defects. Springer US 2012-05-09 2012 /pmc/articles/PMC3400755/ /pubmed/22569734 http://dx.doi.org/10.1007/s10856-012-4663-x Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Van Leeuwen, A. C.
Van Kooten, T. G.
Grijpma, D. W.
Bos, R. R. M.
In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats
title In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats
title_full In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats
title_fullStr In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats
title_full_unstemmed In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats
title_short In vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats
title_sort in vivo behaviour of a biodegradable poly(trimethylene carbonate) barrier membrane: a histological study in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400755/
https://www.ncbi.nlm.nih.gov/pubmed/22569734
http://dx.doi.org/10.1007/s10856-012-4663-x
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