Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients

Aging and neurodegeneration are often accompanied by a functionally impaired ubiquitin–proteasome system (UPS). In tauopathies and polyglutamine diseases, a mutant form of ubiquitin B (UBB(+1)) accumulates in disease-specific aggregates. UBB(+1) mRNA is generated at low levels in vivo during transcr...

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Detalles Bibliográficos
Autores principales: Irmler, Martin, Gentier, Romina J. G., Dennissen, Frank J. A., Schulz, Holger, Bolle, Ines, Hölter, Sabine M., Kallnik, Magdalena, Cheng, Jing Jun, Klingenspor, Martin, Rozman, Jan, Ehrhardt, Nicole, Hermes, Denise J. H. P., Gailus-Durner, Valérie, Fuchs, Helmut, Hrabě de Angelis, Martin, Meyer, Helmut E., Hopkins, David A., Van Leeuwen, Fred W., Beckers, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400757/
https://www.ncbi.nlm.nih.gov/pubmed/22730000
http://dx.doi.org/10.1007/s00401-012-1003-7

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