Hydrogen Peroxide Alters Splicing of Soluble Guanylyl Cyclase and Selectively Modulates Expression of Splicing Regulators in Human Cancer Cells

BACKGROUND: Soluble guanylyl cyclase (sGC) plays a central role in nitric oxide (NO)-mediated signal transduction in the cardiovascular, nervous and gastrointestinal systems. Alternative RNA splicing has emerged as a potential mechanism to modulate sGC expression and activity. C-α1 sGC is an alterna...

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Detalles Bibliográficos
Autores principales: Cote, Gilbert J., Zhu, Wen, Thomas, Anthony, Martin, Emil, Murad, Ferid, Sharina, Iraida G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401163/
https://www.ncbi.nlm.nih.gov/pubmed/22911749
http://dx.doi.org/10.1371/journal.pone.0041099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401163/
https://www.ncbi.nlm.nih.gov/pubmed/22911749
http://dx.doi.org/10.1371/journal.pone.0041099

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