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Mitochondrial DNA Maintenance Is Regulated in Human Hepatoma Cells by Glycogen Synthase Kinase 3β and p53 in Response to Tumor Necrosis Factor α

During chronic liver inflammation, up-regulated Tumor Necrosis Factor alpha (TNF-α) targets hepatocytes and induces abnormal reactive oxygen species (ROS) production responsible for mitochondrial DNA (mtDNA) alterations. The serine/threonine Glycogen Synthase Kinase 3 beta (GSK3β) plays a pivotal ro...

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Detalles Bibliográficos
Autores principales:	Vadrot, Nathalie, Ghanem, Sarita, Braut, Françoise, Gavrilescu, Laura, Pilard, Nathalie, Mansouri, Abdellah, Moreau, Richard, Reyl-Desmars, Florence
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401193/ https://www.ncbi.nlm.nih.gov/pubmed/22911714 http://dx.doi.org/10.1371/journal.pone.0040879

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