Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex

During V(D)J recombination, the RAG1/2 recombinase is thought to play an active role in transferring newly excised recombination ends from the RAG post-cleavage complex (PCC) to the non-homologous end joining (NHEJ) machinery to promote appropriate antigen receptor gene assembly. However, this trans...

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Detalles Bibliográficos
Autores principales: Wang, Guannan, Dhar, Kajari, Swanson, Patrick C., Levitus, Marcia, Chang, Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401440/
https://www.ncbi.nlm.nih.gov/pubmed/22434887
http://dx.doi.org/10.1093/nar/gks255

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