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Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase

X-ray crystallography provides excellent structural data on protein–DNA interfaces, but crystallographic complexes typically contain only small fragments of large DNA molecules. We present a new approach that can use longer DNA substrates and reveal new protein–DNA interactions even in extensively s...

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Detalles Bibliográficos
Autores principales:	Roberts, Victoria A., Pique, Michael E., Hsu, Simon, Li, Sheng, Slupphaug, Geir, Rambo, Robert P., Jamison, Jonathan W., Liu, Tong, Lee, Jun H., Tainer, John A., Ten Eyck, Lynn F., Woods, Virgil L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401472/ https://www.ncbi.nlm.nih.gov/pubmed/22492624 http://dx.doi.org/10.1093/nar/gks291

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