Harnessing human plasmacytoid dendritic cells as professional APCs

The plasmacytoid dendritic cell (pDC) constitutes a unique DC subset that links the innate and adaptive arm of the immune system. Whereas the unique capability of pDCs to produce large amounts of type I IFNs in response to pathogen recognition is generally accepted, their antigen-presenting function...

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Autores principales: Tel, Jurjen, van der Leun, Anne M., Figdor, Carl G., Torensma, Ruurd, de Vries, I. Jolanda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Focussed Research Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401502/
https://www.ncbi.nlm.nih.gov/pubmed/22294456
http://dx.doi.org/10.1007/s00262-012-1210-z
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author Tel, Jurjen
van der Leun, Anne M.
Figdor, Carl G.
Torensma, Ruurd
de Vries, I. Jolanda M.
author_facet Tel, Jurjen
van der Leun, Anne M.
Figdor, Carl G.
Torensma, Ruurd
de Vries, I. Jolanda M.
author_sort Tel, Jurjen
collection PubMed
description The plasmacytoid dendritic cell (pDC) constitutes a unique DC subset that links the innate and adaptive arm of the immune system. Whereas the unique capability of pDCs to produce large amounts of type I IFNs in response to pathogen recognition is generally accepted, their antigen-presenting function is often neglected since most studies on antigen presentation are aimed at other DC subsets. Recently, pDCs were demonstrated capable to present antigen leading to protective tumor immunity. In this review, we discuss how pDCs could be exploited in the fight against cancer by analyzing their capacity to capture, process and (cross-) present antigen.
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spelling pubmed-34015022012-07-23 Harnessing human plasmacytoid dendritic cells as professional APCs Tel, Jurjen van der Leun, Anne M. Figdor, Carl G. Torensma, Ruurd de Vries, I. Jolanda M. Cancer Immunol Immunother Focussed Research Review The plasmacytoid dendritic cell (pDC) constitutes a unique DC subset that links the innate and adaptive arm of the immune system. Whereas the unique capability of pDCs to produce large amounts of type I IFNs in response to pathogen recognition is generally accepted, their antigen-presenting function is often neglected since most studies on antigen presentation are aimed at other DC subsets. Recently, pDCs were demonstrated capable to present antigen leading to protective tumor immunity. In this review, we discuss how pDCs could be exploited in the fight against cancer by analyzing their capacity to capture, process and (cross-) present antigen. Springer-Verlag 2012-02-01 2012 /pmc/articles/PMC3401502/ /pubmed/22294456 http://dx.doi.org/10.1007/s00262-012-1210-z Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Focussed Research Review
Tel, Jurjen
van der Leun, Anne M.
Figdor, Carl G.
Torensma, Ruurd
de Vries, I. Jolanda M.
Harnessing human plasmacytoid dendritic cells as professional APCs
title Harnessing human plasmacytoid dendritic cells as professional APCs
title_full Harnessing human plasmacytoid dendritic cells as professional APCs
title_fullStr Harnessing human plasmacytoid dendritic cells as professional APCs
title_full_unstemmed Harnessing human plasmacytoid dendritic cells as professional APCs
title_short Harnessing human plasmacytoid dendritic cells as professional APCs
title_sort harnessing human plasmacytoid dendritic cells as professional apcs
topic Focussed Research Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401502/
https://www.ncbi.nlm.nih.gov/pubmed/22294456
http://dx.doi.org/10.1007/s00262-012-1210-z
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