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Evolving models of tumor origin and progression
History of cancer disease models clearly illustrates the evolving nature of these concepts. Since such models undergo continual revisions and additions as a result of underlying medical research, they also tend to reorganize knowledge and allow perceiving previously unseen relationships. Growth of m...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401506/ https://www.ncbi.nlm.nih.gov/pubmed/22492238 http://dx.doi.org/10.1007/s13277-012-0389-0 |
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author | Mitrus, Iwona Bryndza, Ewa Sochanik, Aleksander Szala, Stanisław |
author_facet | Mitrus, Iwona Bryndza, Ewa Sochanik, Aleksander Szala, Stanisław |
author_sort | Mitrus, Iwona |
collection | PubMed |
description | History of cancer disease models clearly illustrates the evolving nature of these concepts. Since such models undergo continual revisions and additions as a result of underlying medical research, they also tend to reorganize knowledge and allow perceiving previously unseen relationships. Growth of medical thought has been influenced for many centuries by an ancient Hippocratic concept of disease seen as a disturbance in bodily “humors.” True mechanisms of cell and tissue injury started to be elucidated only with the advent of postmortem pathological findings. Concerning cancer, when first disease-producing bacteria were identified in the nineteenth century, also neoplasms were treated as infectious diseases. Foreign organisms were thought to be present inside tumors. However, this hypothesis could not be confirmed by microscopic or histochemical studies. The latter suggested, instead, that tumors were rather formed by abnormal cells. Cancer was then started to be regarded as a disease of cells. This interpretation was radically altered by later developments in genetics which suggested that neoplasms can be treated as genetic diseases as pathologic cellular lesions are caused by mutations in specific genes. More recent models have compared carcinogenesis to evolutionary processes. Due to genetic instability, successive mutations, appearing in cells, lead to selection of cancer cells which feature specific phenotypic traits. The newest data indicate that there may be also a link between cancer and mutated stem cells. The review discusses main concepts of tumor origin forwarded since the beginnings of the nineteenth century. |
format | Online Article Text |
id | pubmed-3401506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-34015062012-07-23 Evolving models of tumor origin and progression Mitrus, Iwona Bryndza, Ewa Sochanik, Aleksander Szala, Stanisław Tumour Biol Review History of cancer disease models clearly illustrates the evolving nature of these concepts. Since such models undergo continual revisions and additions as a result of underlying medical research, they also tend to reorganize knowledge and allow perceiving previously unseen relationships. Growth of medical thought has been influenced for many centuries by an ancient Hippocratic concept of disease seen as a disturbance in bodily “humors.” True mechanisms of cell and tissue injury started to be elucidated only with the advent of postmortem pathological findings. Concerning cancer, when first disease-producing bacteria were identified in the nineteenth century, also neoplasms were treated as infectious diseases. Foreign organisms were thought to be present inside tumors. However, this hypothesis could not be confirmed by microscopic or histochemical studies. The latter suggested, instead, that tumors were rather formed by abnormal cells. Cancer was then started to be regarded as a disease of cells. This interpretation was radically altered by later developments in genetics which suggested that neoplasms can be treated as genetic diseases as pathologic cellular lesions are caused by mutations in specific genes. More recent models have compared carcinogenesis to evolutionary processes. Due to genetic instability, successive mutations, appearing in cells, lead to selection of cancer cells which feature specific phenotypic traits. The newest data indicate that there may be also a link between cancer and mutated stem cells. The review discusses main concepts of tumor origin forwarded since the beginnings of the nineteenth century. Springer Netherlands 2012-04-11 /pmc/articles/PMC3401506/ /pubmed/22492238 http://dx.doi.org/10.1007/s13277-012-0389-0 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Review Mitrus, Iwona Bryndza, Ewa Sochanik, Aleksander Szala, Stanisław Evolving models of tumor origin and progression |
title | Evolving models of tumor origin and progression |
title_full | Evolving models of tumor origin and progression |
title_fullStr | Evolving models of tumor origin and progression |
title_full_unstemmed | Evolving models of tumor origin and progression |
title_short | Evolving models of tumor origin and progression |
title_sort | evolving models of tumor origin and progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401506/ https://www.ncbi.nlm.nih.gov/pubmed/22492238 http://dx.doi.org/10.1007/s13277-012-0389-0 |
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