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Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer

Voltage-gated Na(+) channels (VGSCs) are heteromeric membrane protein complexes containing pore-forming α subunits and smaller, non-pore-forming β subunits. VGSCs are classically expressed in excitable cells, including neurons and muscle cells, where they mediate action potential firing, neurite out...

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Detalles Bibliográficos
Autores principales:	Yang, Ming, Kozminski, David J., Wold, Lindsey A., Modak, Rohan, Calhoun, Jeffrey D., Isom, Lori L., Brackenbury, William J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2012
Materias:	Preclinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401508/ https://www.ncbi.nlm.nih.gov/pubmed/22678159 http://dx.doi.org/10.1007/s10549-012-2102-9

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