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The specific targeting of immune regulation: T-cell responses against Indoleamine 2,3-dioxygenase
Indoleamine 2,3-dioxygenase (IDO) is an immunoregulatory enzyme that is implicated in suppressing T-cell immunity in many settings including cancer. In recent years, we have described spontaneous CD8(+) as well as CD4(+) T-cell reactivity against IDO in the tumor microenvironment of different cancer...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer-Verlag
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401509/ https://www.ncbi.nlm.nih.gov/pubmed/22388712 http://dx.doi.org/10.1007/s00262-012-1234-4 |