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Effect of Atypical Antipsychotics on Fetal Growth: Is the Placenta Involved?

There is currently considerable uncertainty regarding prescribing practices for pregnant women with severe and persistent psychiatric disorders. The physician and the mother have to balance the risks of untreated psychiatric illness against the potential fetal toxicity associated with pharmacologica...

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Detalles Bibliográficos
Autores principales: Raha, Sandeep, Taylor, Valerie H., Holloway, Alison C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401548/
https://www.ncbi.nlm.nih.gov/pubmed/22848828
http://dx.doi.org/10.1155/2012/315203
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author Raha, Sandeep
Taylor, Valerie H.
Holloway, Alison C.
author_facet Raha, Sandeep
Taylor, Valerie H.
Holloway, Alison C.
author_sort Raha, Sandeep
collection PubMed
description There is currently considerable uncertainty regarding prescribing practices for pregnant women with severe and persistent psychiatric disorders. The physician and the mother have to balance the risks of untreated psychiatric illness against the potential fetal toxicity associated with pharmacological exposure. This is especially true for women taking atypical antipsychotics. Although these drugs have limited evidence for teratological risk, there are reports of altered fetal growth, both increased and decreased, with maternal atypical antipsychotic use. These effects may be mediated through changes in the maternal metabolism which in turn impacts placental function. However, the presence of receptors targeted by atypical antipsychotics in cell lineages present in the placenta suggests that these drugs can also have direct effects on placental function and development. The signaling pathways involved in linking the effects of atypical antipsychotics to placental dysfunction, ultimately resulting in altered fetal growth, remain elusive. This paper focuses on some possible pathways which may link atypical antipsychotics to placental dysfunction.
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spelling pubmed-34015482012-07-30 Effect of Atypical Antipsychotics on Fetal Growth: Is the Placenta Involved? Raha, Sandeep Taylor, Valerie H. Holloway, Alison C. J Pregnancy Review Article There is currently considerable uncertainty regarding prescribing practices for pregnant women with severe and persistent psychiatric disorders. The physician and the mother have to balance the risks of untreated psychiatric illness against the potential fetal toxicity associated with pharmacological exposure. This is especially true for women taking atypical antipsychotics. Although these drugs have limited evidence for teratological risk, there are reports of altered fetal growth, both increased and decreased, with maternal atypical antipsychotic use. These effects may be mediated through changes in the maternal metabolism which in turn impacts placental function. However, the presence of receptors targeted by atypical antipsychotics in cell lineages present in the placenta suggests that these drugs can also have direct effects on placental function and development. The signaling pathways involved in linking the effects of atypical antipsychotics to placental dysfunction, ultimately resulting in altered fetal growth, remain elusive. This paper focuses on some possible pathways which may link atypical antipsychotics to placental dysfunction. Hindawi Publishing Corporation 2012 2012-07-11 /pmc/articles/PMC3401548/ /pubmed/22848828 http://dx.doi.org/10.1155/2012/315203 Text en Copyright © 2012 Sandeep Raha et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Raha, Sandeep
Taylor, Valerie H.
Holloway, Alison C.
Effect of Atypical Antipsychotics on Fetal Growth: Is the Placenta Involved?
title Effect of Atypical Antipsychotics on Fetal Growth: Is the Placenta Involved?
title_full Effect of Atypical Antipsychotics on Fetal Growth: Is the Placenta Involved?
title_fullStr Effect of Atypical Antipsychotics on Fetal Growth: Is the Placenta Involved?
title_full_unstemmed Effect of Atypical Antipsychotics on Fetal Growth: Is the Placenta Involved?
title_short Effect of Atypical Antipsychotics on Fetal Growth: Is the Placenta Involved?
title_sort effect of atypical antipsychotics on fetal growth: is the placenta involved?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401548/
https://www.ncbi.nlm.nih.gov/pubmed/22848828
http://dx.doi.org/10.1155/2012/315203
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