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Thyroid function and bone mineral density among Indian subjects
BACKGROUND: Thyroid hormones affect bone remodeling in patients with thyroid disease by acting directly or indirectly on bone cells. In view of limited information on correlation of thyroid function with bone mineral density (BMD) in euthyroid subjects, we undertook this study to evaluate the correl...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401759/ https://www.ncbi.nlm.nih.gov/pubmed/22837919 http://dx.doi.org/10.4103/2230-8210.98014 |
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author | Marwaha, Raman K. Garg, M. K. Tandon, Nikhil Kanwar, Ratnesh Narang, Aparna Sastry, Archna Bhadra, Kuntal |
author_facet | Marwaha, Raman K. Garg, M. K. Tandon, Nikhil Kanwar, Ratnesh Narang, Aparna Sastry, Archna Bhadra, Kuntal |
author_sort | Marwaha, Raman K. |
collection | PubMed |
description | BACKGROUND: Thyroid hormones affect bone remodeling in patients with thyroid disease by acting directly or indirectly on bone cells. In view of limited information on correlation of thyroid function with bone mineral density (BMD) in euthyroid subjects, we undertook this study to evaluate the correlation between thyroid function with BMD in subjects with normal thyroid function and subclinical hypothyroidism. MATERIAL AND METHODS: A total of 1290 subjects included in this cross sectional study, were divided in Group-1 with normal thyroid function and Group-2 with subclinical hypothyroidism. Fasting blood samples were drawn for the estimation of serum 25(OH)D, intact parathyroid hormone, total and ionized calcium, inorganic phosphorus, and alkaline phosphatase. BMD at lumbar spine, femur, and forearm was measured. RESULTS: BMD at all sites (radius, femur, and spine) were comparable in both groups. There was no difference in BMD when subjects were divided in tertiles of TSH in either group. In group-1, FT4 and TSH were positively associated with BMD at 33% radius whereas FT3 was negatively associated with BMD at femoral neck in multiple regression analysis after adjustment for age, sex, BMI, 25(OH)D and PTH levels. In group-2, there was no association observed between TSH and BMD at any site. Amongst all study subjects FT4 and FT3 were positively correlated with BMD at lumbar spine and radius respectively among all subjects. CONCLUSION: TSH does not affect BMD in euthyroid subjects and subjects with subclinical hypothyroidism. Thyroid hormones appear to have more pronounced positive effect on cortical than trabecular bone in euthyroid subjects. |
format | Online Article Text |
id | pubmed-3401759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-34017592012-07-26 Thyroid function and bone mineral density among Indian subjects Marwaha, Raman K. Garg, M. K. Tandon, Nikhil Kanwar, Ratnesh Narang, Aparna Sastry, Archna Bhadra, Kuntal Indian J Endocrinol Metab Original Article BACKGROUND: Thyroid hormones affect bone remodeling in patients with thyroid disease by acting directly or indirectly on bone cells. In view of limited information on correlation of thyroid function with bone mineral density (BMD) in euthyroid subjects, we undertook this study to evaluate the correlation between thyroid function with BMD in subjects with normal thyroid function and subclinical hypothyroidism. MATERIAL AND METHODS: A total of 1290 subjects included in this cross sectional study, were divided in Group-1 with normal thyroid function and Group-2 with subclinical hypothyroidism. Fasting blood samples were drawn for the estimation of serum 25(OH)D, intact parathyroid hormone, total and ionized calcium, inorganic phosphorus, and alkaline phosphatase. BMD at lumbar spine, femur, and forearm was measured. RESULTS: BMD at all sites (radius, femur, and spine) were comparable in both groups. There was no difference in BMD when subjects were divided in tertiles of TSH in either group. In group-1, FT4 and TSH were positively associated with BMD at 33% radius whereas FT3 was negatively associated with BMD at femoral neck in multiple regression analysis after adjustment for age, sex, BMI, 25(OH)D and PTH levels. In group-2, there was no association observed between TSH and BMD at any site. Amongst all study subjects FT4 and FT3 were positively correlated with BMD at lumbar spine and radius respectively among all subjects. CONCLUSION: TSH does not affect BMD in euthyroid subjects and subjects with subclinical hypothyroidism. Thyroid hormones appear to have more pronounced positive effect on cortical than trabecular bone in euthyroid subjects. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3401759/ /pubmed/22837919 http://dx.doi.org/10.4103/2230-8210.98014 Text en Copyright: © Indian Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Marwaha, Raman K. Garg, M. K. Tandon, Nikhil Kanwar, Ratnesh Narang, Aparna Sastry, Archna Bhadra, Kuntal Thyroid function and bone mineral density among Indian subjects |
title | Thyroid function and bone mineral density among Indian subjects |
title_full | Thyroid function and bone mineral density among Indian subjects |
title_fullStr | Thyroid function and bone mineral density among Indian subjects |
title_full_unstemmed | Thyroid function and bone mineral density among Indian subjects |
title_short | Thyroid function and bone mineral density among Indian subjects |
title_sort | thyroid function and bone mineral density among indian subjects |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401759/ https://www.ncbi.nlm.nih.gov/pubmed/22837919 http://dx.doi.org/10.4103/2230-8210.98014 |
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