Copy number variation and susceptibility to complex traits

Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this issue that is desi...

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Autores principales: Canales, Cesar P, Walz, Katherina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2011
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401997/
https://www.ncbi.nlm.nih.gov/pubmed/21204264
http://dx.doi.org/10.1002/emmm.201000111
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author Canales, Cesar P
Walz, Katherina
author_facet Canales, Cesar P
Walz, Katherina
author_sort Canales, Cesar P
collection PubMed
description Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this issue that is designed to identify human disease-relevant phenotypes associated with CNV in the mouse can help elucidating susceptibility or predisposition to diseases loci.
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spelling pubmed-34019972012-09-17 Copy number variation and susceptibility to complex traits Canales, Cesar P Walz, Katherina EMBO Mol Med Closeup Copy number variations (CNV) within the genome are extremely abundant. In this closeup, Canales and Walz discuss how CNV are associated with normal variation, genomic disorders, genome evolution, adaptive traits and how the use of a novel screen described by Ermakova et al in this issue that is designed to identify human disease-relevant phenotypes associated with CNV in the mouse can help elucidating susceptibility or predisposition to diseases loci. WILEY-VCH Verlag 2011-01 /pmc/articles/PMC3401997/ /pubmed/21204264 http://dx.doi.org/10.1002/emmm.201000111 Text en Copyright © 2011 EMBO Molecular Medicine
spellingShingle Closeup
Canales, Cesar P
Walz, Katherina
Copy number variation and susceptibility to complex traits
title Copy number variation and susceptibility to complex traits
title_full Copy number variation and susceptibility to complex traits
title_fullStr Copy number variation and susceptibility to complex traits
title_full_unstemmed Copy number variation and susceptibility to complex traits
title_short Copy number variation and susceptibility to complex traits
title_sort copy number variation and susceptibility to complex traits
topic Closeup
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401997/
https://www.ncbi.nlm.nih.gov/pubmed/21204264
http://dx.doi.org/10.1002/emmm.201000111
work_keys_str_mv AT canalescesarp copynumbervariationandsusceptibilitytocomplextraits
AT walzkatherina copynumbervariationandsusceptibilitytocomplextraits

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