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Differences in Prevalence, Extent, Severity, and Prognosis of Coronary Artery Disease Among Patients With and Without Diabetes Undergoing Coronary Computed Tomography Angiography: Results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry

OBJECTIVE: We examined the prevalence, extent, severity, and prognosis of coronary artery disease (CAD) in individuals with and without diabetes (DM) who are similar in CAD risk factors. RESEARCH DESIGN AND METHODS: We identified 23,643 consecutive individuals without known CAD undergoing coronary c...

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Autores principales: Rana, Jamal S., Dunning, Allison, Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor Y., Chinnaiyan, Kavitha, Chow, Benjamin J.W., Cury, Ricardo, Delago, Augustin, Feuchtner, Gudrun, Hadamitzky, Martin, Hausleiter, Jörg, Kaufmann, Philipp, Karlsberg, Ronald P., Kim, Yong-Jin, Leipsic, Jonathon, Labounty, Troy M., Lin, Fay Y., Maffei, Erica, Raff, Gilbert, Villines, Todd C., Shaw, Leslee J., Berman, Daniel S., Min, James K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402246/
https://www.ncbi.nlm.nih.gov/pubmed/22699296
http://dx.doi.org/10.2337/dc11-2403
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author Rana, Jamal S.
Dunning, Allison
Achenbach, Stephan
Al-Mallah, Mouaz
Budoff, Matthew J.
Cademartiri, Filippo
Callister, Tracy Q.
Chang, Hyuk-Jae
Cheng, Victor Y.
Chinnaiyan, Kavitha
Chow, Benjamin J.W.
Cury, Ricardo
Delago, Augustin
Feuchtner, Gudrun
Hadamitzky, Martin
Hausleiter, Jörg
Kaufmann, Philipp
Karlsberg, Ronald P.
Kim, Yong-Jin
Leipsic, Jonathon
Labounty, Troy M.
Lin, Fay Y.
Maffei, Erica
Raff, Gilbert
Villines, Todd C.
Shaw, Leslee J.
Berman, Daniel S.
Min, James K.
author_facet Rana, Jamal S.
Dunning, Allison
Achenbach, Stephan
Al-Mallah, Mouaz
Budoff, Matthew J.
Cademartiri, Filippo
Callister, Tracy Q.
Chang, Hyuk-Jae
Cheng, Victor Y.
Chinnaiyan, Kavitha
Chow, Benjamin J.W.
Cury, Ricardo
Delago, Augustin
Feuchtner, Gudrun
Hadamitzky, Martin
Hausleiter, Jörg
Kaufmann, Philipp
Karlsberg, Ronald P.
Kim, Yong-Jin
Leipsic, Jonathon
Labounty, Troy M.
Lin, Fay Y.
Maffei, Erica
Raff, Gilbert
Villines, Todd C.
Shaw, Leslee J.
Berman, Daniel S.
Min, James K.
author_sort Rana, Jamal S.
collection PubMed
description OBJECTIVE: We examined the prevalence, extent, severity, and prognosis of coronary artery disease (CAD) in individuals with and without diabetes (DM) who are similar in CAD risk factors. RESEARCH DESIGN AND METHODS: We identified 23,643 consecutive individuals without known CAD undergoing coronary computed tomography angiography. A total of 3,370 DM individuals were propensity matched in a 1-to-2 fashion to 6,740 unique non-DM individuals. CAD was defined as none, nonobstructive (1–49% stenosis), or obstructive (≥50% stenosis). All-cause mortality was assessed by risk-adjusted Cox proportional hazards models. RESULTS: At a 2.2-year follow-up, 108 (3.2%) and 115 (1.7%) deaths occurred among DM and non-DM individuals, respectively. Compared with non-DM individuals, DM individuals possessed higher rates of obstructive CAD (37 vs. 27%) and lower rates of having normal arteries (28 vs. 36%) (P < 0.0001). CAD extent was higher for DM versus non-DM individuals for obstructive one-vessel disease (19 vs. 14%), two-vessel disease (9 vs. 7%), and three-vessel disease (9 vs. 5%) (P < 0.0001 for comparison), with higher per-segment stenosis in the proximal and mid-segments of every coronary artery (P < 0.001 for all). Compared with non-DM individuals with no CAD, risk of mortality for DM individuals was higher for those with no CAD (hazard ratio 3.63 [95% CI 1.67–7.91]; P = 0.001), nonobstructive CAD (5.25 [2.56–10.8]; P < 0.001), one-vessel disease (6.39 [2.98–13.7]; P < 0.0001), two-vessel disease (12.33 [5.622–27.1]; P < 0.0001), and three-vessel disease (13.25 [6.15–28.6]; P < 0.0001). CONCLUSIONS: Compared with matched non-DM individuals, DM individuals possess higher prevalence, extent, and severity of CAD. At comparable levels of CAD, DM individuals experience higher risk of mortality compared with non-DM individuals.
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spelling pubmed-34022462013-08-01 Differences in Prevalence, Extent, Severity, and Prognosis of Coronary Artery Disease Among Patients With and Without Diabetes Undergoing Coronary Computed Tomography Angiography: Results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry Rana, Jamal S. Dunning, Allison Achenbach, Stephan Al-Mallah, Mouaz Budoff, Matthew J. Cademartiri, Filippo Callister, Tracy Q. Chang, Hyuk-Jae Cheng, Victor Y. Chinnaiyan, Kavitha Chow, Benjamin J.W. Cury, Ricardo Delago, Augustin Feuchtner, Gudrun Hadamitzky, Martin Hausleiter, Jörg Kaufmann, Philipp Karlsberg, Ronald P. Kim, Yong-Jin Leipsic, Jonathon Labounty, Troy M. Lin, Fay Y. Maffei, Erica Raff, Gilbert Villines, Todd C. Shaw, Leslee J. Berman, Daniel S. Min, James K. Diabetes Care Original Research OBJECTIVE: We examined the prevalence, extent, severity, and prognosis of coronary artery disease (CAD) in individuals with and without diabetes (DM) who are similar in CAD risk factors. RESEARCH DESIGN AND METHODS: We identified 23,643 consecutive individuals without known CAD undergoing coronary computed tomography angiography. A total of 3,370 DM individuals were propensity matched in a 1-to-2 fashion to 6,740 unique non-DM individuals. CAD was defined as none, nonobstructive (1–49% stenosis), or obstructive (≥50% stenosis). All-cause mortality was assessed by risk-adjusted Cox proportional hazards models. RESULTS: At a 2.2-year follow-up, 108 (3.2%) and 115 (1.7%) deaths occurred among DM and non-DM individuals, respectively. Compared with non-DM individuals, DM individuals possessed higher rates of obstructive CAD (37 vs. 27%) and lower rates of having normal arteries (28 vs. 36%) (P < 0.0001). CAD extent was higher for DM versus non-DM individuals for obstructive one-vessel disease (19 vs. 14%), two-vessel disease (9 vs. 7%), and three-vessel disease (9 vs. 5%) (P < 0.0001 for comparison), with higher per-segment stenosis in the proximal and mid-segments of every coronary artery (P < 0.001 for all). Compared with non-DM individuals with no CAD, risk of mortality for DM individuals was higher for those with no CAD (hazard ratio 3.63 [95% CI 1.67–7.91]; P = 0.001), nonobstructive CAD (5.25 [2.56–10.8]; P < 0.001), one-vessel disease (6.39 [2.98–13.7]; P < 0.0001), two-vessel disease (12.33 [5.622–27.1]; P < 0.0001), and three-vessel disease (13.25 [6.15–28.6]; P < 0.0001). CONCLUSIONS: Compared with matched non-DM individuals, DM individuals possess higher prevalence, extent, and severity of CAD. At comparable levels of CAD, DM individuals experience higher risk of mortality compared with non-DM individuals. American Diabetes Association 2012-08 2012-07-14 /pmc/articles/PMC3402246/ /pubmed/22699296 http://dx.doi.org/10.2337/dc11-2403 Text en © 2012 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Rana, Jamal S.
Dunning, Allison
Achenbach, Stephan
Al-Mallah, Mouaz
Budoff, Matthew J.
Cademartiri, Filippo
Callister, Tracy Q.
Chang, Hyuk-Jae
Cheng, Victor Y.
Chinnaiyan, Kavitha
Chow, Benjamin J.W.
Cury, Ricardo
Delago, Augustin
Feuchtner, Gudrun
Hadamitzky, Martin
Hausleiter, Jörg
Kaufmann, Philipp
Karlsberg, Ronald P.
Kim, Yong-Jin
Leipsic, Jonathon
Labounty, Troy M.
Lin, Fay Y.
Maffei, Erica
Raff, Gilbert
Villines, Todd C.
Shaw, Leslee J.
Berman, Daniel S.
Min, James K.
Differences in Prevalence, Extent, Severity, and Prognosis of Coronary Artery Disease Among Patients With and Without Diabetes Undergoing Coronary Computed Tomography Angiography: Results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry
title Differences in Prevalence, Extent, Severity, and Prognosis of Coronary Artery Disease Among Patients With and Without Diabetes Undergoing Coronary Computed Tomography Angiography: Results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry
title_full Differences in Prevalence, Extent, Severity, and Prognosis of Coronary Artery Disease Among Patients With and Without Diabetes Undergoing Coronary Computed Tomography Angiography: Results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry
title_fullStr Differences in Prevalence, Extent, Severity, and Prognosis of Coronary Artery Disease Among Patients With and Without Diabetes Undergoing Coronary Computed Tomography Angiography: Results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry
title_full_unstemmed Differences in Prevalence, Extent, Severity, and Prognosis of Coronary Artery Disease Among Patients With and Without Diabetes Undergoing Coronary Computed Tomography Angiography: Results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry
title_short Differences in Prevalence, Extent, Severity, and Prognosis of Coronary Artery Disease Among Patients With and Without Diabetes Undergoing Coronary Computed Tomography Angiography: Results from 10,110 individuals from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes): an InteRnational Multicenter Registry
title_sort differences in prevalence, extent, severity, and prognosis of coronary artery disease among patients with and without diabetes undergoing coronary computed tomography angiography: results from 10,110 individuals from the confirm (coronary ct angiography evaluation for clinical outcomes): an international multicenter registry
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402246/
https://www.ncbi.nlm.nih.gov/pubmed/22699296
http://dx.doi.org/10.2337/dc11-2403
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