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Genetic Risk Score Constructed Using 14 Susceptibility Alleles for Type 2 Diabetes Is Associated With the Early Onset of Diabetes and May Predict the Future Requirement of Insulin Injections Among Japanese Individuals

OBJECTIVE: We evaluated the clinical usefulness of a genetic risk score (GRS) based on 14 well-established variants for type 2 diabetes. RESEARCH DESIGN AND METHODS: We analyzed 14 SNPs at HHEX, CDKAL1, CDKN2B, SLC30A8, KCNJ11, IGF2BP2, PPARG, TCF7L2, FTO, KCNQ1, IRS-1, GCKR, UBE2E2, and C2CD4A/B in...

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Detalles Bibliográficos
Autores principales:	Iwata, Minoru, Maeda, Shiro, Kamura, Yutaka, Takano, Atsuko, Kato, Hiromi, Murakami, Shihou, Higuchi, Kiyohiro, Takahashi, Atsushi, Fujita, Hayato, Hara, Kazuo, Kadowaki, Takashi, Tobe, Kazuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402252/ https://www.ncbi.nlm.nih.gov/pubmed/22688542 http://dx.doi.org/10.2337/dc11-2006

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