Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure?

The overall role of modification of β-cell antigens in type 1 diabetes has not been elucidated and was the focus of a recent workshop on posttranslational modification of proteins in type 1 diabetes. The prevailing opinion of the workshop attendees was that novel insights into the mechanism of loss...

Descripción completa

Detalles Bibliográficos
Autores principales: Dunne, Jessica L., Overbergh, Lut, Purcell, Anthony W., Mathieu, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Perspectives in Diabetes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402302/
https://www.ncbi.nlm.nih.gov/pubmed/22826307
http://dx.doi.org/10.2337/db11-1675
_version_ 1782238727662206976
author Dunne, Jessica L.
Overbergh, Lut
Purcell, Anthony W.
Mathieu, Chantal
author_facet Dunne, Jessica L.
Overbergh, Lut
Purcell, Anthony W.
Mathieu, Chantal
author_sort Dunne, Jessica L.
collection PubMed
description The overall role of modification of β-cell antigens in type 1 diabetes has not been elucidated and was the focus of a recent workshop on posttranslational modification of proteins in type 1 diabetes. The prevailing opinion of the workshop attendees was that novel insights into the mechanism of loss of immune tolerance might be gained and that novel diagnostic and therapeutic approaches could be developed for type 1 diabetes if protein modifications were shown to play a critical role in the disease.
format Online
Article
Text
id pubmed-3402302
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher American Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-34023022013-08-01 Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure? Dunne, Jessica L. Overbergh, Lut Purcell, Anthony W. Mathieu, Chantal Diabetes Perspectives in Diabetes The overall role of modification of β-cell antigens in type 1 diabetes has not been elucidated and was the focus of a recent workshop on posttranslational modification of proteins in type 1 diabetes. The prevailing opinion of the workshop attendees was that novel insights into the mechanism of loss of immune tolerance might be gained and that novel diagnostic and therapeutic approaches could be developed for type 1 diabetes if protein modifications were shown to play a critical role in the disease. American Diabetes Association 2012-08 2012-07-17 /pmc/articles/PMC3402302/ /pubmed/22826307 http://dx.doi.org/10.2337/db11-1675 Text en © 2012 by the American Diabetes Association. https://creativecommons.org/licenses/by-nc-nd/3.0/Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ (https://creativecommons.org/licenses/by-nc-nd/3.0/) for details.
spellingShingle Perspectives in Diabetes
Dunne, Jessica L.
Overbergh, Lut
Purcell, Anthony W.
Mathieu, Chantal
Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure?
title Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure?
title_full Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure?
title_fullStr Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure?
title_full_unstemmed Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure?
title_short Posttranslational Modifications of Proteins in Type 1 Diabetes: The Next Step in Finding the Cure?
title_sort posttranslational modifications of proteins in type 1 diabetes: the next step in finding the cure?
topic Perspectives in Diabetes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402302/
https://www.ncbi.nlm.nih.gov/pubmed/22826307
http://dx.doi.org/10.2337/db11-1675
work_keys_str_mv AT dunnejessical posttranslationalmodificationsofproteinsintype1diabetesthenextstepinfindingthecure
AT overberghlut posttranslationalmodificationsofproteinsintype1diabetesthenextstepinfindingthecure
AT purcellanthonyw posttranslationalmodificationsofproteinsintype1diabetesthenextstepinfindingthecure
AT mathieuchantal posttranslationalmodificationsofproteinsintype1diabetesthenextstepinfindingthecure

Ejemplares similares