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G Protein–Coupled Receptor Kinase 2, With β-Arrestin 2, Impairs Insulin-Induced Akt/Endothelial Nitric Oxide Synthase Signaling in ob/ob Mouse Aorta

In type 2 diabetes, impaired insulin-induced Akt/endothelial nitric oxide synthase (eNOS) signaling may decrease the vascular relaxation response. Previously, we reported that this response was negatively regulated by G protein–coupled receptor kinase 2 (GRK2). In this study, we investigated whether...

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Detalles Bibliográficos
Autores principales:	Taguchi, Kumiko, Matsumoto, Takayuki, Kamata, Katsuo, Kobayashi, Tsuneo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402304/ https://www.ncbi.nlm.nih.gov/pubmed/22688330 http://dx.doi.org/10.2337/db11-1729

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