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Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes
Mitochondrial reactive oxygen species (ROS) cause kidney damage in diabetes. We investigated the source and site of ROS production by kidney cortical tubule mitochondria in streptozotocin-induced type 1 diabetes in rats. In diabetic mitochondria, the increased amounts and activities of selective fat...
Autores principales: | Rosca, Mariana G., Vazquez, Edwin J., Chen, Qun, Kerner, Janos, Kern, Timothy S., Hoppel, Charles L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402323/ https://www.ncbi.nlm.nih.gov/pubmed/22586586 http://dx.doi.org/10.2337/db11-1437 |
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