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Oxidative Stress–Induced JNK1/2 Activation Triggers Proapoptotic Signaling and Apoptosis That Leads to Diabetic Embryopathy

Oxidative stress and apoptosis are implicated in the pathogenesis of diabetic embryopathy. The proapoptotic c-Jun NH(2)-terminal kinases (JNK)1/2 activation is associated with diabetic embryopathy. We sought to determine whether 1) hyperglycemia-induced oxidative stress is responsible for the activa...

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Detalles Bibliográficos
Autores principales:	Li, Xuezheng, Weng, Hongbo, Xu, Cheng, Reece, E. Albert, Yang, Peixin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Complications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402327/ https://www.ncbi.nlm.nih.gov/pubmed/22688338 http://dx.doi.org/10.2337/db11-1624

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