Massively parallel functional dissection of mammalian enhancers in vivo

The functional consequences of genetic variation in mammalian regulatory elements are poorly understood. We report the in vivo dissection of three mammalian liver enhancers at single nucleotide resolution via a massively parallelized reporter assay. For each enhancer, we synthesized a library of >...

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Detalles Bibliográficos
Autores principales: Patwardhan, Rupali P, Hiatt, Joseph B, Witten, Daniela M, Kim, Mee J, Smith, Robin P, May, Dalit, Lee, Choli, Andrie, Jennifer M, Lee, Su-In, Cooper, Gregory M, Ahituv, Nadav, Pennacchio, Len A, Shendure, Jay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402344/
https://www.ncbi.nlm.nih.gov/pubmed/22371081
http://dx.doi.org/10.1038/nbt.2136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402344/
https://www.ncbi.nlm.nih.gov/pubmed/22371081
http://dx.doi.org/10.1038/nbt.2136

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