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Conformational Analysis of Clostridium difficile Toxin B and Its Implications for Substrate Recognition
Clostridium difficile (C. difficile) is an opportunistic pathogen that can cause potentially lethal hospital-acquired infections. The cellular damage that it causes is the result of two large clostridial cytotoxins: TcdA and TcdB which act by glucosylating cytosolic G-proteins, mis-regulation of whi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402401/ https://www.ncbi.nlm.nih.gov/pubmed/22844485 http://dx.doi.org/10.1371/journal.pone.0041518 |