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Efficient Recombinant Production in Mammalian Cells Using a Novel IR/MAR Gene Amplification Method
We previously found that plasmids bearing a mammalian replication initiation region (IR) and a nuclear matrix attachment region (MAR) efficiently initiate gene amplification and spontaneously increase their copy numbers in animal cells. In this study, this novel method was applied to the establishme...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402416/ https://www.ncbi.nlm.nih.gov/pubmed/22844523 http://dx.doi.org/10.1371/journal.pone.0041787 |