The Effects of Simvastatin or Interferon-α on Infectivity of Human Norovirus Using a Gnotobiotic Pig Model for the Study of Antivirals

The lack of an animal model for human norovirus (HuNoV) has hindered the development of therapeutic strategies. This study demonstrated that a commonly used cholesterol-lowering statin medication, simvastatin, which increases HuNoV replication in an in vitro replicon system, also enhances HuNoV infe...

Descripción completa

Detalles Bibliográficos
Autores principales: Jung, Kwonil, Wang, Qiuhong, Kim, Yunjeong, Scheuer, Kelly, Zhang, Zhenwen, Shen, Quan, Chang, Kyeong-Ok, Saif, Linda J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402445/
https://www.ncbi.nlm.nih.gov/pubmed/22911825
http://dx.doi.org/10.1371/journal.pone.0041619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402445/
https://www.ncbi.nlm.nih.gov/pubmed/22911825
http://dx.doi.org/10.1371/journal.pone.0041619

Ejemplares similares