Clonal Analysis in Recurrent Astrocytic, Oligoastrocytic and Oligodendroglial Tumors Implicates IDH1- Mutation as Common Tumor Initiating Event

BACKGROUND: To investigate the dynamics of inter- and intratumoral molecular alterations during tumor progression in recurrent gliomas. METHODOLOGY/PRINCIPAL FINDINGS: To address intertumoral heterogeneity we investigated non- microdissected tumor tissue of 106 gliomas representing 51 recurrent tumo...

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Detalles Bibliográficos
Autores principales: Lass, Ulrike, Nümann, Astrid, von Eckardstein, Kajetan, Kiwit, Jürgen, Stockhammer, Florian, Horaczek, Jörn A., Veelken, Julian, Herold-Mende, Christel, Jeuken, Judith, von Deimling, Andreas, Mueller, Wolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402513/
https://www.ncbi.nlm.nih.gov/pubmed/22844452
http://dx.doi.org/10.1371/journal.pone.0041298

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