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Effects of acetylcholine on neuronal properties in entorhinal cortex
The entorhinal cortex (EC) receives prominent cholinergic innervation from the medial septum and the vertical limb of the diagonal band of Broca (MSDB). To understand how cholinergic neurotransmission can modulate behavior, research has been directed toward identification of the specific cellular me...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402879/ https://www.ncbi.nlm.nih.gov/pubmed/22837741 http://dx.doi.org/10.3389/fnbeh.2012.00032 |
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author | Heys, James G. Schultheiss, Nathan W. Shay, Christopher F. Tsuno, Yusuke Hasselmo, Michael E. |
author_facet | Heys, James G. Schultheiss, Nathan W. Shay, Christopher F. Tsuno, Yusuke Hasselmo, Michael E. |
author_sort | Heys, James G. |
collection | PubMed |
description | The entorhinal cortex (EC) receives prominent cholinergic innervation from the medial septum and the vertical limb of the diagonal band of Broca (MSDB). To understand how cholinergic neurotransmission can modulate behavior, research has been directed toward identification of the specific cellular mechanisms in EC that can be modulated through cholinergic activity. This review focuses on intrinsic cellular properties of neurons in EC that may underlie functions such as working memory, spatial processing, and episodic memory. In particular, the study of stellate cells (SCs) in medial entorhinal has resulted in discovery of correlations between physiological properties of these neurons and properties of the unique spatial representation that is demonstrated through unit recordings of neurons in medial entorhinal cortex (mEC) from awake-behaving animals. A separate line of investigation has demonstrated persistent firing behavior among neurons in EC that is enhanced by cholinergic activity and could underlie working memory. There is also evidence that acetylcholine plays a role in modulation of synaptic transmission that could also enhance mnemonic function in EC. Finally, the local circuits of EC demonstrate a variety of interneuron physiology, which is also subject to cholinergic modulation. Together these effects alter the dynamics of EC to underlie the functional role of acetylcholine in memory. |
format | Online Article Text |
id | pubmed-3402879 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-34028792012-07-26 Effects of acetylcholine on neuronal properties in entorhinal cortex Heys, James G. Schultheiss, Nathan W. Shay, Christopher F. Tsuno, Yusuke Hasselmo, Michael E. Front Behav Neurosci Neuroscience The entorhinal cortex (EC) receives prominent cholinergic innervation from the medial septum and the vertical limb of the diagonal band of Broca (MSDB). To understand how cholinergic neurotransmission can modulate behavior, research has been directed toward identification of the specific cellular mechanisms in EC that can be modulated through cholinergic activity. This review focuses on intrinsic cellular properties of neurons in EC that may underlie functions such as working memory, spatial processing, and episodic memory. In particular, the study of stellate cells (SCs) in medial entorhinal has resulted in discovery of correlations between physiological properties of these neurons and properties of the unique spatial representation that is demonstrated through unit recordings of neurons in medial entorhinal cortex (mEC) from awake-behaving animals. A separate line of investigation has demonstrated persistent firing behavior among neurons in EC that is enhanced by cholinergic activity and could underlie working memory. There is also evidence that acetylcholine plays a role in modulation of synaptic transmission that could also enhance mnemonic function in EC. Finally, the local circuits of EC demonstrate a variety of interneuron physiology, which is also subject to cholinergic modulation. Together these effects alter the dynamics of EC to underlie the functional role of acetylcholine in memory. Frontiers Media S.A. 2012-07-24 /pmc/articles/PMC3402879/ /pubmed/22837741 http://dx.doi.org/10.3389/fnbeh.2012.00032 Text en Copyright © 2012 Heys, Schultheiss, Shay, Tsuno and Hasselmo. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Neuroscience Heys, James G. Schultheiss, Nathan W. Shay, Christopher F. Tsuno, Yusuke Hasselmo, Michael E. Effects of acetylcholine on neuronal properties in entorhinal cortex |
title | Effects of acetylcholine on neuronal properties in entorhinal cortex |
title_full | Effects of acetylcholine on neuronal properties in entorhinal cortex |
title_fullStr | Effects of acetylcholine on neuronal properties in entorhinal cortex |
title_full_unstemmed | Effects of acetylcholine on neuronal properties in entorhinal cortex |
title_short | Effects of acetylcholine on neuronal properties in entorhinal cortex |
title_sort | effects of acetylcholine on neuronal properties in entorhinal cortex |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402879/ https://www.ncbi.nlm.nih.gov/pubmed/22837741 http://dx.doi.org/10.3389/fnbeh.2012.00032 |
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