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Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases

Patients with rheumatic diseases have an increased risk of mortality by cardiovascular events. In fact, several rheumatic diseases such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, and ankylosing spondylitis are associated with a higher prevalence of cardiovascular diseases...

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Autores principales: Scotece, Morena, Conde, Javier, Gómez, Rodolfo, López, Verónica, Pino, Jesús, González, Antonio, Lago, Francisca, Gómez-Reino, Juan J., Gualillo, Oreste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403095/
https://www.ncbi.nlm.nih.gov/pubmed/22910888
http://dx.doi.org/10.1155/2012/125458
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author Scotece, Morena
Conde, Javier
Gómez, Rodolfo
López, Verónica
Pino, Jesús
González, Antonio
Lago, Francisca
Gómez-Reino, Juan J.
Gualillo, Oreste
author_facet Scotece, Morena
Conde, Javier
Gómez, Rodolfo
López, Verónica
Pino, Jesús
González, Antonio
Lago, Francisca
Gómez-Reino, Juan J.
Gualillo, Oreste
author_sort Scotece, Morena
collection PubMed
description Patients with rheumatic diseases have an increased risk of mortality by cardiovascular events. In fact, several rheumatic diseases such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, and ankylosing spondylitis are associated with a higher prevalence of cardiovascular diseases (CVDs). Although traditional cardiovascular risk factors have been involved in the pathogenesis of cardiovascular diseases in rheumatic patients, these alterations do not completely explain the enhanced cardiovascular risk in this population. Obesity and its pathologic alteration of fat mass and dysfunction, due to an altered pattern of secretion of proinflammatory adipokines, could be one of the links between cardiovascular and rheumatic diseases. Indeed, the incidence of CVDs is augmented in obese individuals with rheumatic disorders. Thus, in this paper we explore in detail the relationships among adipokines, rheumatic diseases, and cardiovascular complications by giving to the reader a holistic vision and several suggestions for future perspectives and potential clinical implications.
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spelling pubmed-34030952012-07-30 Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases Scotece, Morena Conde, Javier Gómez, Rodolfo López, Verónica Pino, Jesús González, Antonio Lago, Francisca Gómez-Reino, Juan J. Gualillo, Oreste Mediators Inflamm Review Article Patients with rheumatic diseases have an increased risk of mortality by cardiovascular events. In fact, several rheumatic diseases such as rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, and ankylosing spondylitis are associated with a higher prevalence of cardiovascular diseases (CVDs). Although traditional cardiovascular risk factors have been involved in the pathogenesis of cardiovascular diseases in rheumatic patients, these alterations do not completely explain the enhanced cardiovascular risk in this population. Obesity and its pathologic alteration of fat mass and dysfunction, due to an altered pattern of secretion of proinflammatory adipokines, could be one of the links between cardiovascular and rheumatic diseases. Indeed, the incidence of CVDs is augmented in obese individuals with rheumatic disorders. Thus, in this paper we explore in detail the relationships among adipokines, rheumatic diseases, and cardiovascular complications by giving to the reader a holistic vision and several suggestions for future perspectives and potential clinical implications. Hindawi Publishing Corporation 2012 2012-07-15 /pmc/articles/PMC3403095/ /pubmed/22910888 http://dx.doi.org/10.1155/2012/125458 Text en Copyright © 2012 Morena Scotece et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Scotece, Morena
Conde, Javier
Gómez, Rodolfo
López, Verónica
Pino, Jesús
González, Antonio
Lago, Francisca
Gómez-Reino, Juan J.
Gualillo, Oreste
Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases
title Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases
title_full Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases
title_fullStr Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases
title_full_unstemmed Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases
title_short Role of Adipokines in Atherosclerosis: Interferences with Cardiovascular Complications in Rheumatic Diseases
title_sort role of adipokines in atherosclerosis: interferences with cardiovascular complications in rheumatic diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403095/
https://www.ncbi.nlm.nih.gov/pubmed/22910888
http://dx.doi.org/10.1155/2012/125458
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