Nardilysin and ADAM proteases promote gastric cancer cell growth by activating intrinsic cytokine signalling via enhanced ectodomain shedding of TNF-α

Nardilysin (NRDc), a metalloendopeptidase of the M16 family, promotes ectodomain shedding of the precursor forms of various growth factors and cytokines by enhancing the protease activities of ADAM proteins. Here, we show the growth-promoting role of NRDc in gastric cancer cells. Analyses of clinica...

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Detalles Bibliográficos
Autores principales: Kanda, Keitaro, Komekado, Hideyuki, Sawabu, Tateo, Ishizu, Shoko, Nakanishi, Yuki, Nakatsuji, Masato, Akitake-Kawano, Reiko, Ohno, Mikiko, Hiraoka, Yoshinori, Kawada, Mayumi, Kawada, Kenji, Sakai, Yoshiharu, Matsumoto, Kyoichi, Kunichika, Makoto, Kimura, Takeshi, Seno, Hiroshi, Nishi, Eiichiro, Chiba, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2012
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403297/
https://www.ncbi.nlm.nih.gov/pubmed/22351606
http://dx.doi.org/10.1002/emmm.201200216

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