A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review

Background. Drug-induced hepatotoxicity (DIH) is quite common, and there are several recommendations for its treatment based upon its etiology. DIH may range from mild and subclinical to fulminant liver failure and death. Even though there is extensive list of drugs causing DIH, antibiotics, as a cl...

Descripción completa

Detalles Bibliográficos
Autores principales: Alam, Mian Bilal, Kadoura, Amin, Sathaiah, Magesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403404/
https://www.ncbi.nlm.nih.gov/pubmed/22844299
http://dx.doi.org/10.1155/2012/953714
_version_ 1782238884661297152
author Alam, Mian Bilal
Kadoura, Amin
Sathaiah, Magesh
author_facet Alam, Mian Bilal
Kadoura, Amin
Sathaiah, Magesh
author_sort Alam, Mian Bilal
collection PubMed
description Background. Drug-induced hepatotoxicity (DIH) is quite common, and there are several recommendations for its treatment based upon its etiology. DIH may range from mild and subclinical to fulminant liver failure and death. Even though there is extensive list of drugs causing DIH, antibiotics, as a class of drugs, are the most common cause of DIH. Here, we present a fatal case of nafcillin-induced hepatotoxicity confirmed by liver biopsy, with total bilirubin peaking to 21.8 mg/dl and subsequent further extensive evaluation for hepatic injury turning out to be negative.
format Online
Article
Text
id pubmed-3403404
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-34034042012-07-27 A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review Alam, Mian Bilal Kadoura, Amin Sathaiah, Magesh Case Rep Med Case Report Background. Drug-induced hepatotoxicity (DIH) is quite common, and there are several recommendations for its treatment based upon its etiology. DIH may range from mild and subclinical to fulminant liver failure and death. Even though there is extensive list of drugs causing DIH, antibiotics, as a class of drugs, are the most common cause of DIH. Here, we present a fatal case of nafcillin-induced hepatotoxicity confirmed by liver biopsy, with total bilirubin peaking to 21.8 mg/dl and subsequent further extensive evaluation for hepatic injury turning out to be negative. Hindawi Publishing Corporation 2012 2012-07-11 /pmc/articles/PMC3403404/ /pubmed/22844299 http://dx.doi.org/10.1155/2012/953714 Text en Copyright © 2012 Mian Bilal Alam et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Alam, Mian Bilal
Kadoura, Amin
Sathaiah, Magesh
A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review
title A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review
title_full A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review
title_fullStr A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review
title_full_unstemmed A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review
title_short A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review
title_sort fatal case of nafcillin-induced hepatotoxicity: a case report and the literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403404/
https://www.ncbi.nlm.nih.gov/pubmed/22844299
http://dx.doi.org/10.1155/2012/953714
work_keys_str_mv AT alammianbilal afatalcaseofnafcillininducedhepatotoxicityacasereportandtheliteraturereview
AT kadouraamin afatalcaseofnafcillininducedhepatotoxicityacasereportandtheliteraturereview
AT sathaiahmagesh afatalcaseofnafcillininducedhepatotoxicityacasereportandtheliteraturereview
AT alammianbilal fatalcaseofnafcillininducedhepatotoxicityacasereportandtheliteraturereview
AT kadouraamin fatalcaseofnafcillininducedhepatotoxicityacasereportandtheliteraturereview
AT sathaiahmagesh fatalcaseofnafcillininducedhepatotoxicityacasereportandtheliteraturereview

Ejemplares similares